Gypenoside LI|cas:94987-10-7|西域试剂

Gypenoside LI,98.29%

产品编号：Bellancom-N8207| CAS NO：94987-10-7| 分子式：C₄₂H₇₂O₁₄| 分子量：801.01

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N8207		￥4500.00	杭州北京（现货）

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Gypenoside LI

产品介绍

Gypenoside LI 是一种绞股蓝赶单体，具有抗肿瘤活性。Gypenoside LI 诱导癌细胞凋亡、细胞周期阻滞和迁移。

生物活性

Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration.

体外研究

Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells.
Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells.
Gypenoside LI could obviously suppress the expression of CDK1 protein rather than CDK2 and CDK4 proteins.
Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells.
Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway.
Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	A549 cells.
Concentration:	0-80 μM.
Incubation Time:	24 h.
Result:	Displayed the strongest activity with the IC₅₀ values of 21.36 ± 0.78 μM.

分子量

801.01

性状

Solid

Formula

C₄₂H₇₂O₁₄

CAS 号

94987-10-7

结构分类

Terpenoids
Triterpenes

初始来源

Plants
Cucurbitaceae
Gynostemma pentaphyllum (Thunb.) Makino

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (124.84 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2484 mL	6.2421 mL	12.4842 mL
5 mM	0.2497 mL	1.2484 mL	2.4968 mL
10 mM	0.1248 mL	0.6242 mL	1.2484 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献