TCV-309 chloride|cas:121494-09-5|西域试剂

TCV-309 chloride,95.0%

产品编号：Bellancom-19121A| CAS NO：121494-09-5| 分子式：C₃₀H₃₄BrClN₄O₄| 分子量：629.97

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货号	价格	库存与货期
Bellancom-19121A	￥2800.00	杭州北京（现货）
Bellancom-19121A	￥4400.00	杭州北京（现货）
Bellancom-19121A	￥8800.00	杭州北京（现货）
Bellancom-19121A	￥14000.00	杭州北京（现货）

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TCV-309 chloride

产品介绍

TCV-309 chloride 是一种有效的，特异性血小板活化因子 (PAF) 拮抗剂。TCV-309 chloride 特异性地抑制 PAF 诱导的兔和人血小板聚集，以及 [3H]PAF 与兔血小板微粒体的结合，IC₅₀ 值分别为 33 nM，58 nM 和 27 nM。TCV-309 chloride 对过敏性休克具有有益作用。

生物活性

TCV-309 chloride is a potent and specific platelet activating factor (PAF) antagonist. TCV-309 chloride specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC₅₀ values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock.

体外研究

体内研究

In rats, TCV-309 selectively inhibits the PAF-induced hypotension, hemoconcentration and death with ED₅₀ values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 most potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively.
TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 6.3 mg/mL (10.00 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5874 mL	7.9369 mL	15.8738 mL
5 mM	0.3175 mL	1.5874 mL	3.1748 mL
10 mM	0.1587 mL	0.7937 mL	1.5874 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献