Sphinganine 1-phosphate D-erythro-Dihydrosphingosine 1-phosphate|cas:19794-97-9|西域试剂

Sphinganine 1-phosphate D-erythro-Dihydrosphingosine 1-phosphate

产品编号：Bellancom-113116| CAS NO：19794-97-9| 分子式：C₁₈H₄₀NO₅P| 分子量：381.49

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-113116		￥3500.00	杭州北京（现货）
Bellancom-113116		￥10800.00	杭州北京（现货）

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Sphinganine 1-phosphate D-erythro-Dihydrosphingosine 1-phosphate

产品介绍

Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) 是一种极性鞘脂代谢物，可调节细胞迁移、细胞分化等众多生理过程。

生物活性

Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes.

体外研究

Sphinganine 1-phosphate (S1P) is a potent signaling molecule involved in cell stress responses, cancer, angiogenesis and lymphocyte trafficking. Sphinganine 1-phosphate functions primarily by activating a subgroup of the endothelial differentiation gene (EDG) family of G-protein coupled cell surface receptors. Sphinganine 1-phosphate has opposite effects in the regulation of cell metabolism. Sphinganine 1-phosphate regulates skeletal muscle differentiation and regeneration.
Sphinganine 1-phosphate (S1P) is involved in cancer. Sphinganine 1-phosphate regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival.
Sphinganine-1-Phosphate (1 μM) phosphorylates ERK MAPK, Akt, and HSP27 and induces HSP27 in human renal endothelial cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Human renal endothelial cells or human kidney proximal tubule (HK-2) cells
Concentration:	1 μM
Incubation Time:	2 or 4 hours
Result:	Induced HSP27 mRNA in cultured human renal endothelial cells. Phosphorylated ERK MAPK and AKT in human renal endothelial cells in a time-dependent manner. Phosphorylated and induced HSP27.

体内研究
(In Vivo)

Sphinganine 1-phosphate can enhance wound healing in diabetic mice. Sphinganine 1-phosphate provides renal and hepatic protection after liver ischemia and reperfusion (IR) injury in mice through selective activation of S1P1 receptors and pertussis toxin-sensitive G-proteins with subsequent activation of ERK and Akt. Sphinganine 1-phosphate (administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion) protects against hepatic and renal injury after liver IR.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice (20-25 g)
Dosage:	0.1 mg/kg
Administration:	Administered i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion
Result:	The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively. The increases in ALT (7474±557 U/L) and Cr (0.55±0.05 mg/dL) were significantly suppressed at 24 h after reperfusion in mice treated with 0.1 mg/kg i.v. before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice (20-25 g)
Dosage:	0.1 mg/kg
Administration:	Administered i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion
Result:	The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively. The increases in ALT (7474±557 U/L) and Cr (0.55±0.05 mg/dL) were significantly suppressed at 24 h after reperfusion in mice treated with 0.1 mg/kg i.v. before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice (20-25 g)
Dosage:	0.1 mg/kg
Administration:	Administered i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion
Result:	The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively. The increases in ALT (7474±557 U/L) and Cr (0.55±0.05 mg/dL) were significantly suppressed at 24 h after reperfusion in mice treated with 0.1 mg/kg i.v. before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion.