Adenosine receptor antagonist 2|cas:2703054-47-9|西域试剂

Adenosine receptor antagonist 2,99.37%

产品编号：Bellancom-144064| CAS NO：2703054-47-9| 分子式：C₂₃H₂₁FN₈O| 分子量：444.46

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-144064		￥7800.00	杭州北京（现货）
Bellancom-144064		￥12500.00	杭州北京（现货）

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Adenosine receptor antagonist 2

产品介绍

Adenosine receptor antagonist 2 是一种口服有效的 A2a/A2b 腺苷受体拮抗剂，IC₅₀ 分别为 1 nM 和 3 nM。Adenosine receptor antagonist 2 具有抗肿瘤活性。

生物活性

Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC₅₀s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity.

体外研究

体内研究

Adenosine receptor antagonist 2 (compound L-1; po; 10, 30, 100 mg/kg; twice a day for 22 days) inhibits tumor growth in female C57BL / 6mice mice with MC38(#22)-hpd-L1 cells.
Adenosine receptor antagonist 2 (iv; 2 mg/kg) has a CLz of 14.7 mL/min·kg and an AUC of 2252 h·ng/mL. Adenosine receptor antagonist 2 (po; 10 mg/kg) has a C_max of 8730 ng/mL in adult male ICR mice (weight 25-40g).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (224.99 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2499 mL	11.2496 mL	22.4992 mL
5 mM	0.4500 mL	2.2499 mL	4.4998 mL
10 mM	0.2250 mL	1.1250 mL	2.2499 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献