Rubropunctatin|cas:514-67-0|西域试剂

Rubropunctatin,98.0%

产品编号：Bellancom-N7766| CAS NO：514-67-0| 分子式：C₂₁H₂₂O₅| 分子量：354.40

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N7766		￥4100.00	杭州北京（现货）
Bellancom-N7766		￥7200.00	杭州北京（现货）

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Rubropunctatin

产品介绍

Rubropunctatin 是一种从红曲霉发酵米(红霉米)提取物中分离出来的橙色的氮杂酮类色素。 Rubropunctatin 具有抗炎，免疫抑制和抗氧化作用，还具有抗肿瘤活性。

生物活性

Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity.

体外研究

Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1.
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells.
Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	BGC-823 and GES-1cells
Concentration:	1.5, 3, 6, 12, 15, 18, 30 μM
Incubation Time:	24 hours
Result:	Decreased the viability of BGC-823 cells with an IC₅₀ of 12.57 μM for 24 h. Did not show obvious cytotoxic effects on the normal cells.

Cell Cycle Analysis

Cell Line:	BGC-823 cells
Concentration:	0, 5, 10, 30 μM
Incubation Time:	0, 6, 12, 24 hours
Result:	Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.

体内研究
(In Vivo)

Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice.
Rubropunctamine inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID₅₀ of 0.11 mg/ear.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male nude mice (5 weeks) are inoculated with BGC-823 cells
Dosage:	8, 32 mg/kg
Administration:	I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result:	Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg). Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg). No significant difference was observed on the body weight.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male nude mice (5 weeks) are inoculated with BGC-823 cells
Dosage:	8, 32 mg/kg
Administration:	I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result:	Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg). Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg). No significant difference was observed on the body weight.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male nude mice (5 weeks) are inoculated with BGC-823 cells
Dosage:	8, 32 mg/kg
Administration:	I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result:	Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg). Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg). No significant difference was observed on the body weight.