Crisnatol BWA770U|cas:96389-68-3|西域试剂

Crisnatol BWA770U,99.51%

产品编号：Bellancom-108999A| CAS NO：96389-68-3| 分子式：C₂₃H₂₃NO₂| 分子量：345.43

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货号	价格	库存与货期
Bellancom-108999A	￥1500.00	杭州北京（现货）
Bellancom-108999A	￥2400.00	杭州北京（现货）
Bellancom-108999A	￥4700.00	杭州北京（现货）
Bellancom-108999A	￥7500.00	杭州北京（现货）
Bellancom-108999A	￥12000.00	杭州北京（现货）

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Crisnatol BWA770U

产品介绍

Crisnatol (BWA770U) 是一种口服有效的抗癌剂和芳甲基氨基丙二醇类 DNA 插入器。Crisnatol 对人类乳腺癌细胞显示出体外细胞毒性，但对正常的人类皮肤成纤维细胞无效。

生物活性

Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts.

体外研究

Crisnatol (1.3 μg/mL; 24-72 h) 抑制 HepG2 细胞的复制，使细胞活力降低 35%。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HepG2 cells
Concentration:	1.3 μg/mL
Incubation Time:	24 hours, 48 hours, 72 hours, and 126 hours
Result:	Inhibited cell viability at 48 hr.

体内研究
(In Vivo)

Crisnatol (25 mg/kg; p.o.; single dose) 显示出口服活性，并通过放射自显影显示大鼠粪便提取物的稳定代谢物谱。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Crisnatol (25 mg/kg; p.o.; single dose) 显示出口服活性，并通过放射自显影显示大鼠粪便提取物的稳定代谢物谱。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Crisnatol (25 mg/kg; p.o.; single dose) 显示出口服活性，并通过放射自显影显示大鼠粪便提取物的稳定代谢物谱。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (289.49 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8949 mL	14.4747 mL	28.9494 mL
5 mM	0.5790 mL	2.8949 mL	5.7899 mL
10 mM	0.2895 mL	1.4475 mL	2.8949 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献