Verrucarin J Muconomycin B|cas:4643-58-7|西域试剂

Verrucarin J Muconomycin B,99.0%

产品编号：Bellancom-N10113| CAS NO：4643-58-7| 分子式：C₂₇H₃₂O₈| 分子量：484.54

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N10113		￥8000.00	杭州北京（现货）

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Verrucarin J Muconomycin B

产品介绍

Verrucarin J (Muconomycin B) 是 Myrothecium 真菌家族的代谢物。Verrucarin J 诱导活性氧 (ROS) 生成和癌细胞系凋亡 (apoptosis)，例如 A549、HCT 116 和 SW-620 细胞。Verrucarin J 具有抗 Candida albicans 和 Mucor miehei 的活性。Verrucarin J 抑制沙粒病毒 Junin (JUNV) 产量，IC₅₀ 为 1.2 ng/mL。

生物活性

Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC₅₀ of 1.2 ng/mL^[4]^[5].

体外研究

Verrucarin J (0, 5, 10, 20, 50 nM; 24 hours) induces the apoptosis of A549 cells.
Verrucarin J (0, 1, 2, 5, 10, 20, 50 nM; 24, 48, 72 hours) significantly inhibits cell proliferation of A549 and H1793 cells with IC₅₀ values of approximately 10 nM and 20 nM after 48 h of treatment, respectively.
Verrucarin J (0, 0.1, 0.2, 0.3, 0.4, 0.5 μM; 24 hours) has an IC₅₀ of 300 nM for HCT 116 and SW-620 cell proliferation.
Verrucarin J (0, 10, 20 nM, 48 hours) inhibits cancer stem cell (CSC) self-renewal pathways Wnt1/β-catenin and Notch1 and down-regulates the expression of key CSC specific genes (ALDH1, LGR5, OCT4 and CD133) of A549 cells.
Verrucarin J (compound 2; 50 μg/disk) shows noteworthy activities against Candida albicans and Mucor miehei.
Verrucarin J reduces JUNV yield more than 2 log units and has a similar effect against the arenavirus Tacaribe^[4].
Verrucarin J reduces the cell viability of Vero cells with a cytotoxic concentration 50% (CC₅₀) of 8.2 ng/mL^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Verrucarin J (0.5 mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model.
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts
Dosage:	0.5 mg/kg body weight
Administration:	i.p. for 4 weeks
Result:	Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors.

Animal Model:	Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts^[5]
Dosage:	0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate)
Administration:	i.p. for three weeks after 10 days of injection of A2780 cells
Result:	Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg. Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg. Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg. In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts
Dosage:	0.5 mg/kg body weight
Administration:	i.p. for 4 weeks
Result:	Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors.

Animal Model:	Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts^[5]
Dosage:	0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate)
Administration:	i.p. for three weeks after 10 days of injection of A2780 cells
Result:	Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg. Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg. Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg. In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments.