myo-Inositol trispyrophosphate hexasodium ITPP hexasodium|cas:23103-35-7|西域试剂

myo-Inositol trispyrophosphate hexasodium ITPP hexasodium,98.0%

产品编号：Bellancom-141510| CAS NO：23103-35-7| 分子式：C₆H₆Na₆O₂₁P₆| 分子量：737.88

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-141510	￥1800.00	杭州北京（现货）
Bellancom-141510	￥3200.00	杭州北京（现货）
Bellancom-141510	￥6800.00	杭州北京（现货）
Bellancom-141510	￥11500.00	杭州北京（现货）

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myo-Inositol trispyrophosphate hexasodium ITPP hexasodium

产品介绍

myo-Inositol trispyrophosphate (ITPP) hexasodium 是血红蛋白 (haemoglobin) 调节剂，是一种变构效应物，可降低血红蛋白的氧结合亲和力并促进红细胞释放氧。myo-Inositol trispyrophosphatehexasodium 可以逆转缺氧，控制肿瘤生长并改善化疗反应。

生物活性

myo-Inositol trispyrophosphate (ITPP) hexasodium, a modifier of haemoglobin, is an allosteric effector that reduces the oxygen‐binding affinity of haemoglobin and facilitates the release of oxygen by red blood cells. myo-Inositol trispyrophosphate can reverse hypoxia, control tumor growth and improve chemotherapy response.

体外研究

myo-Inositol trispyrophosphate hexasodium (10 mmol/L; 2 hours) significantly inhibits OCR in all six cell lines (FSaII, SiHa, MDA‐MB‐231, NT2, 9L‐glioma and rhabdomyosarcoma) .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

myo-Inositol trispyrophosphate hexasodium (2 g/kg weekly; IP; 7weeks) sustains its significant effect on life prolongation.
myo-Inositol trispyrophosphate hexasodium (1.5 g/kg weekly; IV; for 8 weeks) remains metastasis-free on pancreatic carcinomas in immunocompetent male Lewis rats weighing 120-150 g with DSL-6A/C1 cells. myo-Inositol trispyrophosphate hexasodium restores the pO2 pressure in tumors reducing hypoxia-inducible and proangiogenic factors.
myo-Inositol trispyrophosphate hexasodium (2 g/kg; once daily for 2 days) shows the most elevated tumour oxygenation at 2 hours in four mouse tumour models (mouse fibrosarcoma FSaII implanted in C3H mice, mouse mammary tumour NT2 in FVb/Nrj mice, human breast cancer MDA‐MB‐231 in NMRI nude mice and human cervix squamous cell carcinoma SiHa in NMRI nude mice) and two rat tumour models (rat 9L‐glioma in Fischer F344 rats and rat rhabdomyosarcoma in WAG/Rij rats).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice (20 g) with MiaPaCa-2 or DSL-6A/C1 cells
Dosage:	2 g/kg (weekly)
Administration:	IP; weekly; 7weeks
Result:	Sustained its significant effect on life prolongation.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice (20 g) with MiaPaCa-2 or DSL-6A/C1 cells
Dosage:	2 g/kg (weekly)
Administration:	IP; weekly; 7weeks
Result:	Sustained its significant effect on life prolongation.

性状

Solid

溶解性数据

In Vitro:

H₂O : 25 mg/mL (33.88 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3552 mL	6.7762 mL	13.5523 mL
5 mM	0.2710 mL	1.3552 mL	2.7105 mL
10 mM	0.1355 mL	0.6776 mL	1.3552 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献