TT-232 CAP-232; TLN-232|cas:147159-51-1|西域试剂

TT-232 CAP-232; TLN-232,98.96%

产品编号：Bellancom-105172| CAS NO：147159-51-1| 分子式：C₄₅H₅₈N₁₀O₉S₂| 分子量：947.13

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货号	价格	库存与货期
Bellancom-105172	￥1800.00	杭州北京（现货）
Bellancom-105172	￥7200.00	杭州北京（现货）
Bellancom-105172	￥10500.00	杭州北京（现货）

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TT-232 CAP-232; TLN-232

产品介绍

TT-232 (CAP-232)，一种生长抑素衍生物，是一种多肽类SSTR1/SSTR4 激动剂。TT-232 抑制癌细胞增殖并诱导细胞凋亡 (apoptosis)。TT-232 也是一种广谱抗炎镇痛剂。

生物活性

TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent^[4].

体外研究

TT-232 (10 μg/mL, 48 h) induces apoptosis in human colon (HT-29 and SW620), pancreatic (818), leukemia (K-562), melanoma (WM 938/B, M-1 and EP) and lymphoma (HT-58) tumor cell lines.
TT-232 (20-30 μg/mL, 24 h) shows antiproliferative effect on various human tumor cell lines.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	MCF7, PC-3, P818, K-562, 4-1ST, ect.
Concentration:	20-30 μg/mL
Incubation Time:	24 h
Result:	Inhibited cell proliferation by 87%, 90%, 98%, 95%, respectively.

体内研究
(In Vivo)

TT-232 (15-750 μg/kg/day, twice a day) inhibits tumor growth in mice transplanted with Colon 26 cell.
TT-232 (0.6 or 15 μg/kg s.c or i.p.) shows antitumor effect on P-388 rodent lymphocytic leukemia tumor mice.
TT-232 (7.5-20 μg/kg, i.v.) inhibits Carrageenin-induced paw oedema in rats^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice transplanted with Colon 26 cell .
Dosage:	15, 150, 750 μg/kg/day
Administration:	Intraperitoneal injection (i.p.)
Result:	Reached 70% tumor inhibition at 750 μg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice transplanted with Colon 26 cell .
Dosage:	15, 150, 750 μg/kg/day
Administration:	Intraperitoneal injection (i.p.)
Result:	Reached 70% tumor inhibition at 750 μg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice transplanted with Colon 26 cell .
Dosage:	15, 150, 750 μg/kg/day
Administration:	Intraperitoneal injection (i.p.)
Result:	Reached 70% tumor inhibition at 750 μg/kg.