T01-1|cas:2356229-14-4|西域试剂

T01-1,98.80%

产品编号：Bellancom-148185| CAS NO：2356229-14-4| 分子式：C₂₆H₂₉N₃O₆S| 分子量：511.59

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-148185		￥8800.00	杭州北京（现货）
Bellancom-148185		￥13200.00	杭州北京（现货）

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T01-1

产品介绍

T01-1 是一种抗癌剂 (喜树碱衍生物)，具有较好的抗肿瘤细胞增殖活性。

生物活性

T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity.

体外研究

T01-1 (0-50 nM; 3 days) anti-proliferative activity in HCC1806 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	HCC1806 cells
Concentration:	0-50 nM
Incubation Time:	3 days
Result:	Inhibited cell proliferation with an EC₅₀ value of 6.7 nM.

体内研究
(In Vivo)

T01-1 (1 mg/kg; i.v.; single) shows T_1/2 values of 2.78 and 1.97 h in female and male rats, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley rat (half male and half female).

Dosage:

1 mg/kg

Administration:

Intravenous injection; single

Result:

1.19 Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat .

	IV (1 mg/kg)
	Female	Male
AUC_Last (ng/mL•h)	437	214
C_max (ng/mL)	838	625
MRT_INF (h)	2.81	0.44
T_1/2 (h)	2.78	1.97
T_max (h)	0.08	0.08

体内研究

T01-1 (1 mg/kg; i.v.; single) shows T_1/2 values of 2.78 and 1.97 h in female and male rats, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley rat (half male and half female).

Dosage:

1 mg/kg

Administration:

Intravenous injection; single

Result:

1.19 Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat .

	IV (1 mg/kg)
	Female	Male
AUC_Last (ng/mL•h)	437	214
C_max (ng/mL)	838	625
MRT_INF (h)	2.81	0.44
T_1/2 (h)	2.78	1.97
T_max (h)	0.08	0.08

体内研究

T01-1 (1 mg/kg; i.v.; single) shows T_1/2 values of 2.78 and 1.97 h in female and male rats, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley rat (half male and half female).

Dosage:

1 mg/kg

Administration:

Intravenous injection; single

Result:

1.19 Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat .

	IV (1 mg/kg)
	Female	Male
AUC_Last (ng/mL•h)	437	214
C_max (ng/mL)	838	625
MRT_INF (h)	2.81	0.44
T_1/2 (h)	2.78	1.97
T_max (h)	0.08	0.08

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

. Li Deliang, et al. Camptothecin derivative and water-soluble prodrug, pharmaceutical composition preparation method, and application. Patent WO2020156189A1.

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