JG-98|cas:1456551-16-8|西域试剂

JG-98,99.75%

产品编号：Bellancom-117282| CAS NO：1456551-16-8| 分子式：C₂₄H₂₁Cl₂N₃OS₃| 分子量：534.54

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货号	价格	库存与货期
Bellancom-117282	￥3500.00	杭州北京（现货）
Bellancom-117282	￥5500.00	杭州北京（现货）
Bellancom-117282	￥0.00	杭州北京（现货）

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JG-98

产品介绍

JG-98 是一种热休克蛋白 70 (Hsp70) 变构抑制剂，可与 Hsp70 上的保守位点紧密结合，打断 Hsp70-Bag3 相互作用。JG-98 影响癌细胞和肿瘤相关巨噬细胞，显示抗癌活性。

生物活性

JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.

体外研究

JG-98 (30 nM-30 μM; 72 hours) has antiproliferative activity across a range of cell lines with the EC₅₀s between ~0.3 and 4 μM.
JG-98 (10 μM; 48 hours) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells.
JG-98 destabilizes FoxM1 and relieves suppression of downstream effectors, including p21 and p27.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	MCF-7, MDA-MB-231, A375, MeWo, HeLa, HT-29, SKOV3, Jurkat, mouse embryonic fibroblasts (MEF), MM1.R, INA6, RPMI-8226, JJN-3, U266, NCI-H929, L363, MM1.S, KMS11, LP-1, AMO-1, OPM1, OPM2 cells
Concentration:	30 nM-30 μM
Incubation Time:	72 hours
Result:	Active against all of the lines tested, and the EC₅₀s were variable (between ~0.3 μM and 4 μM). Normal MEFs and OPM1 and OPM2 were relatively less sensitive.

Western Blot Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	10 μM
Incubation Time:	48 hours
Result:	Incudes apoptotic mediators cleavage of caspase 3 and PARP.

体内研究
(In Vivo)

JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week-old NCR mice (xenografts of MCF7 and HeLa cells)
Dosage:	3 mg/kg
Administration:	Intraperitoneal injection; on days 0, 2, and 4
Result:	Limited tumor growth, but somewhat less effectively.

体内研究

JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week-old NCR mice (xenografts of MCF7 and HeLa cells)
Dosage:	3 mg/kg
Administration:	Intraperitoneal injection; on days 0, 2, and 4
Result:	Limited tumor growth, but somewhat less effectively.

体内研究

JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week-old NCR mice (xenografts of MCF7 and HeLa cells)
Dosage:	3 mg/kg
Administration:	Intraperitoneal injection; on days 0, 2, and 4
Result:	Limited tumor growth, but somewhat less effectively.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (9.35 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8708 mL	9.3538 mL	18.7077 mL
5 mM	0.3742 mL	1.8708 mL	3.7415 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献