Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer.

Glychionide A (3.12-100 μM) significantly inhibits the proliferation of the PANC-1 pancreatic cancer cells, with an IC₅₀ of 14 μM.
Glychionide A (7-28 μM) induces both autophagy and apoptosis in pancreatic cancer cells.
Glychionide A (7-28 μM) causes G2/M arrest of PANC-1 pancreatic cancer cells.
Glychionide A (7-28 μM) causes generation of ROS in PANC-1 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Li JR, et, al. Two new compounds from Glycyrrhiza glabra. J Asian Nat Prod Res. 2005 Aug;7(4):677-80.  [Content Brief]

  . Yu L, et, al. Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential. Med Sci Monit. 2019 Feb  [Content Brief]