SJ6986|cas:2765625-93-0|西域试剂

SJ6986,98.55%

产品编号：Bellancom-132199| CAS NO：2765625-93-0| 分子式：C₂₀H₁₄F₃N₃O₇S| 分子量：497.40

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-132199	￥3000.00	杭州北京（现货）
Bellancom-132199	￥4800.00	杭州北京（现货）
Bellancom-132199	￥9500.00	杭州北京（现货）
Bellancom-132199	￥14500.00	杭州北京（现货）
Bellancom-132199	￥22500.00	杭州北京（现货）

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SJ6986

产品介绍

SJ6986 是有效的、选择性的、口服有效的 GSPT1/2 降解剂，其对GSPT1 的DC₅₀ 值为2.1 nM (D_max 99%)。

生物活性

SJ6986 is a potent, selective and orally active GSPT1/2 degrader, with a DC₅₀ of 2.1 nM (D_max 99%) for GSPT1.

体外研究

SJ6986 exhibits EC₅₀ values of 1.5 nM, 0.4 nM, 726 nM, 336 nM and 3583 nM in MV4-11, MHH-CALL-4, MB002, MB004 and HD-MB03 cell lines, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	MV4-11 cells.
Concentration:	0-100 μM.
Incubation Time:	3 days.
Result:	Exhibited EC₅₀ of 1.5 nM.

Western Blot Analysis

Cell Line:	MV4-11 cells.
Concentration:	0-10 μM.
Incubation Time:	4 and 24 h.
Result:	Dose- and time-dependently decreased the protein levels of GSPT1.

体内研究
(In Vivo)

SJ6986 exhibits t_1/2 of 3.44 h by iv injection of 3 mg/kg and t_max of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SJ6986 exhibits t_1/2 of 3.44 h by iv injection of 3 mg/kg and t_max of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SJ6986 exhibits t_1/2 of 3.44 h by iv injection of 3 mg/kg and t_max of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (201.05 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0105 mL	10.0523 mL	20.1045 mL
5 mM	0.4021 mL	2.0105 mL	4.0209 mL
10 mM	0.2010 mL	1.0052 mL	2.0105 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.03 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.03 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明