SIRT7 inhibitor 97491|cas:1807758-81-1|西域试剂

SIRT7 inhibitor 97491,98.03%

产品编号：Bellancom-135899| CAS NO：1807758-81-1| 分子式：C₁₅H₁₂ClN₃O| 分子量：285.73

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货号	价格	库存与货期
Bellancom-135899	￥3000.00	杭州北京（现货）
Bellancom-135899	￥4500.00	杭州北京（现货）
Bellancom-135899	￥9000.00	杭州北京（现货）
Bellancom-135899	￥14500.00	杭州北京（现货）

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SIRT7 inhibitor 97491

产品介绍

SIRT7 inhibitor 97491 是一种有效的 SIRT7 抑制剂，IC₅₀ 为 325 nM，SIRT7 inhibitor 97491 降低 SIRT7 去乙酰化酶活性，这种作用存在剂量依赖性。SIRT7 inhibitor 97491 通过在 K373/382 处进行乙酰化来提高 p53 的稳定性，从而防止肿瘤进展。SIRT7 inhibitor 97491 通过 caspase 途径促进凋亡 (apoptosis)。

生物活性

SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC₅₀ of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..

体外研究

SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	Human uterine sarcoma MES-SA cells
Concentration:	1, 5, 10 μM
Incubation Time:	72 hours
Result:	Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM.

Cell Cytotoxicity Assay

Cell Line:	Human embryonic kidney cell line HEK293 cells
Concentration:	1, 5, 10 μM
Incubation Time:	24 hours
Result:	HEK293 cells were almost unaffected.

体内研究
(In Vivo)

SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells
Dosage:	2 mg/kg
Administration:	Intraperitoneally injected; for 3 weeks, except on weekends.
Result:	Inhibited cancer growth in vivo.

体内研究

SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells
Dosage:	2 mg/kg
Administration:	Intraperitoneally injected; for 3 weeks, except on weekends.
Result:	Inhibited cancer growth in vivo.

体内研究

SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells
Dosage:	2 mg/kg
Administration:	Intraperitoneally injected; for 3 weeks, except on weekends.
Result:	Inhibited cancer growth in vivo.

性状

Solid

溶解性数据

In Vitro:

DMSO : 500 mg/mL (1749.90 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.4998 mL	17.4990 mL	34.9981 mL
5 mM	0.7000 mL	3.4998 mL	6.9996 mL
10 mM	0.3500 mL	1.7499 mL	3.4998 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 4.17 mg/mL (14.59 mM); Clear solution

此方案可获得 ≥ 4.17 mg/mL (14.59 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 41.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。