4E1RCat|cas:328998-25-0|西域试剂

4E1RCat,99.10%

产品编号：Bellancom-14427| CAS NO：328998-25-0| 分子式：C₂₈H₁₈N₂O₆| 分子量：478.45

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货号	价格	库存与货期
Bellancom-14427	￥800.00	杭州北京（现货）
Bellancom-14427	￥1100.00	杭州北京（现货）
Bellancom-14427	￥2500.00	杭州北京（现货）
Bellancom-14427	￥4500.00	杭州北京（现货）

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4E1RCat

产品介绍

4E1RCat 是一种 cap 依赖性翻译抑制剂，能够抑制 eIF4E:eIF4GI 相互作用，IC₅₀ 值约为 4 μM。

生物活性

4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC₅₀ an of ∼4 μM.

体外研究

4E1RCat is an inhibitor of eIF4E:eIF4GI interaction, with an IC₅₀ an of ∼4 μM. 4E1RCat binding to eIF4E also interferes with eIF4G and 4E-BP binding. 4E1RCat inhibits ribosome recruitment to mRNA in a cap-dependent manner. 4E1RCat blocks the capped mRNA translation, and the translation is activated by CDK1/CYCB1. Nearly all new protein synthesis in both mitosis and interphase is cap-dependent and -sensitive to 4E1RCat treatment, in HeLa and U2OS cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

4E1RCat (15 mg/kg, i.p.) affacts chemosensitivity of Pten^+/-Eμ-Myc tumors in mice. 4E1RCat (15 mg/kg, i.p.) sensitizes Pten^+/-Eμ-Myc and Tsc2^+/-Eμ-Myc lymphomas to the cytotoxic effects of doxorubicin (Dxr), and 4E1RCat targets translation in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 18.33 mg/mL (38.31 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0901 mL	10.4504 mL	20.9008 mL
5 mM	0.4180 mL	2.0901 mL	4.1802 mL
10 mM	0.2090 mL	1.0450 mL	2.0901 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式