IACS-9571 hydrochloride ASIS-P040 hydrochloride|cas:2319611-93-1|西域试剂

IACS-9571 hydrochloride ASIS-P040 hydrochloride,99.85%

产品编号：Bellancom-102000B| CAS NO：2319611-93-1| 分子式：C₃₂H₄₃ClN₄O₈S| 分子量：679.22

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货号	价格	库存与货期
Bellancom-102000B	￥1200.00	杭州北京（现货）
Bellancom-102000B	￥3500.00	杭州北京（现货）
Bellancom-102000B	￥6500.00	杭州北京（现货）
Bellancom-102000B	￥22500.00	杭州北京（现货）
Bellancom-102000B	￥33000.00	杭州北京（现货）

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IACS-9571 hydrochloride ASIS-P040 hydrochloride

产品介绍

IACS-9571 (ASIS-P040) hydrochloride 是溴结构域蛋白 TRIM24 和 BRPF1 的抑制剂，对 TRIM24 的 IC₅₀ 和 K_d 值分别为 8 nM 和 31 nM，对 BRPF1 的 K_d 值为 14 nM。

生物活性

IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC₅₀ of 8 nM for TRIM24, and K_ds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

体外研究

IACS-9571 Hydrochloride shows excellent cellular potency with EC₅₀ of 50 nM. IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (K_d=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (184.03 mM; Need ultrasonic and warming)

H₂O : 10 mg/mL (14.72 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4723 mL	7.3614 mL	14.7228 mL
5 mM	0.2945 mL	1.4723 mL	2.9446 mL
10 mM	0.1472 mL	0.7361 mL	1.4723 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献