ACY-1083,98.0%
产品编号:Bellancom-111791| CAS NO:1708113-43-2| 分子式:C17H18F2N4O2| 分子量:348.35
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ACY-1083
产品介绍 | ACY-1083 是一种可渗透脑的选择性 HDAC6 抑制剂,IC50 为 3 nM,ACY-1083 对 HDAC6 的选择性比其他类别的 HDAC 亚型高 260 倍。ACY-1083 可有效逆转化疗引起的周围神经病变。 | ||||||||||||||||
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生物活性 | ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy. | ||||||||||||||||
体外研究 |
Treatment with ACY-1083 (30 and 300 nM) significantly improves cell viability in a dose-dependent manner. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay
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体内研究 (In Vivo) |
ACY-1083 (i.p.; 10 mg/kg; for 7 days) effectively relieves Cisplatin-induced mechanical allodynia in C57BL/6J mice 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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体内研究 |
ACY-1083 (i.p.; 10 mg/kg; for 7 days) effectively relieves Cisplatin-induced mechanical allodynia in C57BL/6J mice 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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体内研究 |
ACY-1083 (i.p.; 10 mg/kg; for 7 days) effectively relieves Cisplatin-induced mechanical allodynia in C57BL/6J mice 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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性状 | Oil | ||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 200 mg/mL (574.14 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) | ||||||||||||||||
参考文献 |
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