GW280264X|cas:866924-39-2|西域试剂

GW280264X,97.36%

产品编号：Bellancom-115670| CAS NO：866924-39-2| 分子式：C₂₈H₄₁N₅O₆S| 分子量：575.72

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-115670	￥4300.00	杭州北京（现货）
Bellancom-115670	￥7500.00	杭州北京（现货）
Bellancom-115670	￥15800.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

GW280264X

产品介绍

GW280264X 是 ADAM10/TACE (ADAM17) 金属蛋白酶抑制剂。GW280264X 有效阻断 TACE (ADAM17) 和 ADAM10，IC₅₀ 分别为 8.0 nM 和 11.5 nM。ADAM10/17 可调节胶质母细胞瘤起始细胞的免疫原性。

生物活性

GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC₅₀s of 8.0 nM and 11.5 nM, respectively. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells.

体外研究

The proliferation of GS-7 cells was significantly reduced upon treatment with GW280264X or ADAM10/17 co-knockdown.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Glioblastoma-initiating cells (GIC) GS-7 cells
Concentration:	0.1, 1, and 3 µM
Incubation Time:	48 hours
Result:	Proliferation of GIC is inhibited through inhibition of ADAM10 and ADAM17.

体内研究
(In Vivo)

Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice
Dosage:	100  µg/kg
Administration:	I.p. injected; every day for one week starting 4 h post-surgery
Result:	Showed significantly improved functional recovery compared to the control group.

体内研究

Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice
Dosage:	100  µg/kg
Administration:	I.p. injected; every day for one week starting 4 h post-surgery
Result:	Showed significantly improved functional recovery compared to the control group.

体内研究

Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice
Dosage:	100  µg/kg
Administration:	I.p. injected; every day for one week starting 4 h post-surgery
Result:	Showed significantly improved functional recovery compared to the control group.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (217.12 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7370 mL	8.6848 mL	17.3696 mL
5 mM	0.3474 mL	1.7370 mL	3.4739 mL
10 mM	0.1737 mL	0.8685 mL	1.7370 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (3.61 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.61 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。