QN523|cas:878581-60-3|西域试剂

QN523,99.77%

产品编号：Bellancom-148255| CAS NO：878581-60-3| 分子式：C₁₄H₁₀N₄O| 分子量：250.26

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-148255	￥1400.00	杭州北京（现货）
Bellancom-148255	￥2200.00	杭州北京（现货）
Bellancom-148255	￥4400.00	杭州北京（现货）
Bellancom-148255	￥6900.00	杭州北京（现货）
Bellancom-148255	￥11000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

QN523

产品介绍

QN523 是一种具有类活性分子性质的新型支架，在 12 种癌细胞株中显示出强大的体外细胞毒性。QN523 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。QN523 可用于癌症的研究。

生物活性

QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer.

体外研究

QN523 (72 h) has cytotoxicity with IC₅₀ values ranging from 0.1 to 5.7 μM across 12 cell lines.
QN523 (0.1 and 0.5 μM; 24 and 48 h; MIA PaCa-2 cells) arrests cell cycle at S phase and delays for pancreatic cancer cells to enter the G2-M phase. QN523 induces apoptosis and autophagy of MIA PaCa-2 Cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis

Cell Line:	MIA PaCa-2 cells
Concentration:	0.1 and 0.5 μM
Incubation Time:	24 and 48 hours
Result:	Delayed for pancreatic cancer cells to enter the G2-M phase because of accumulation of cells in the S phase.

Apoptosis Analysis

Cell Line:	MIA PaCa-2 cells
Concentration:	0.1 and 0.5 μM
Incubation Time:	24 and 48 hours
Result:	Increased the number of apoptotic cell in time- and dose-dependent manner.

体内研究
(In Vivo)

QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD/SCID mice of pancreatic cancer xenografts (6 weeks of age)
Dosage:	10 and 20 mg/kg
Administration:	Intraperitoneal administration; 1-9 days (10 mg/kg), 10-44 days (20 mg/kg)
Result:	Delayed growth of the tumors, and no systemic toxicity.

体内研究

QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD/SCID mice of pancreatic cancer xenografts (6 weeks of age)
Dosage:	10 and 20 mg/kg
Administration:	Intraperitoneal administration; 1-9 days (10 mg/kg), 10-44 days (20 mg/kg)
Result:	Delayed growth of the tumors, and no systemic toxicity.

体内研究

QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD/SCID mice of pancreatic cancer xenografts (6 weeks of age)
Dosage:	10 and 20 mg/kg
Administration:	Intraperitoneal administration; 1-9 days (10 mg/kg), 10-44 days (20 mg/kg)
Result:	Delayed growth of the tumors, and no systemic toxicity.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 16.67 mg/mL (66.61 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.9958 mL	19.9792 mL	39.9584 mL
5 mM	0.7992 mL	3.9958 mL	7.9917 mL
10 mM	0.3996 mL	1.9979 mL	3.9958 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献