Edoxaban 依度沙班; DU-176|cas:480449-70-5|西域试剂

Edoxaban 依度沙班; DU-176,99.59%

产品编号：Bellancom-10264| CAS NO：480449-70-5| 分子式：C₂₄H₃₀ClN₇O₄S| 分子量：548.06

Edoxaban(DU-176)是口服的FXa抑制剂，临床开发用于中风预防。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-10264	￥500.00	杭州北京（现货）
Bellancom-10264	￥700.00	杭州北京（现货）
Bellancom-10264	￥1300.00	杭州北京（现货）
Bellancom-10264	￥1800.00	杭州北京（现货）

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Edoxaban 依度沙班; DU-176

产品介绍

Edoxaban (DU-176b) 是一种具有口服活性、高效、选择性和直接的 Factor Xa (FXa) 抑制剂，对人游离 FXa 和凝血酶原酶的 K_i 值分别为 0.561 nM 和 2.98 nM。Edoxaban 的选择性是其他凝血蛋白酶的 10000 倍以上。Edoxaban 可用于预防血栓栓塞性疾病的研究。

生物活性

Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with K_i values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research.

体外研究

Edoxaban (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner.
Edoxaban inhibits thrombin-induced platelet aggregation, with an IC₅₀ of 2.90 µM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Human, rat, cynomolgus monkey and rabbit plasma; Human platelet
Concentration:
Incubation Time:	1 and 5 minutes
Result:	Antithrombin.

体内研究
(In Vivo)

Edoxaban (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:	0.5, 2.5 and 12.5 mg/kg
Administration:	Oral administration; once
Result:	Inhibited exogenous FXa activity. Antithrombotic.

体内研究

Edoxaban (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:	0.5, 2.5 and 12.5 mg/kg
Administration:	Oral administration; once
Result:	Inhibited exogenous FXa activity. Antithrombotic.

体内研究

Edoxaban (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:	0.5, 2.5 and 12.5 mg/kg
Administration:	Oral administration; once
Result:	Inhibited exogenous FXa activity. Antithrombotic.

性状

Solid

溶解性数据

In Vitro:

DMSO : 10 mg/mL (18.25 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8246 mL	9.1231 mL	18.2462 mL
5 mM	0.3649 mL	1.8246 mL	3.6492 mL
10 mM	0.1825 mL	0.9123 mL	1.8246 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9. [Content Brief]

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产品编号(Item Number)

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Edoxaban 依度沙班; DU-176,99.59%

Edoxaban 依度沙班; DU-176

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