Girinimbine Girinimbin|cas:23095-44-5|西域试剂

Girinimbine Girinimbin

产品编号：Bellancom-N9488| CAS NO：23095-44-5| 分子式：C₁₈H₁₇NO| 分子量：263.33

吉利宁（Girinimbin）是一种咔唑类生物碱，具有多种生物效应。吉利宁可诱导细胞凋亡，具有抗锥体细胞、抗血小板活性、抗菌活性、抗炎、抗氧化和抗肿瘤活性。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N9488		￥4000.00	杭州北京（现货）
Bellancom-N9488		￥10000.00	杭州北京（现货）

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Girinimbine Girinimbin

产品介绍

Girinimbine (Girinimbin) 是一种咔唑类生物碱，具有多种生物学作用。Girinimbine 可诱导细胞凋亡 (apoptosis)，具有抗锥虫、抗血小板活性、抗菌活性、抗炎、抗氧化和抗肿瘤活性。

生物活性

Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities.

体外研究

Girinimbine (1-400 µM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC₅₀ values of 61 µM, 56 µM, and 40 µM respectively. Girinimbine (10-100 µM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells.
Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells. HepG2 cells.
Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest.
Girinimbine shows a potent antitrypanosomal activitywith an IC₅₀ value of 10.16 µg/mL.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HepG2 cells
Concentration:	1 µM, 10 µM, 50 µM, 100 µM, 200 µM
Incubation Time:	24 h, 48 h and 72 h
Result:	Inhibited the proliferation of HepG2 cells in vitro in a dose- and time-dependent manner.

Apoptosis Analysis

Cell Line:	HepG2 cells
Concentration:	56 µM
Incubation Time:	24 h, 48 h
Result:	Showed typical morphological features of apoptosis.

Cell Cycle Analysis

Cell Line:	HepG2 cells
Concentration:	56 µM
Incubation Time:	12 h, 24 h, 48 h
Result:	Induced G0/G1-phase arrest in HepG2 cells.

体内研究
(In Vivo)

Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid.
In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR mice (25-35 g) treated with carrageenan
Dosage:	10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration:	Orally gavage; once
Result:	Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR mice (25-35 g) treated with carrageenan
Dosage:	10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration:	Orally gavage; once
Result:	Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR mice (25-35 g) treated with carrageenan
Dosage:	10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration:	Orally gavage; once
Result:	Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献

. Suvitha Syam, et al. The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest. Molecules. 2011 Aug 23;16(8):7155-70. [Content Brief]

. Venoos Iman, et al. Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. Drug Des Devel Ther. 2016 Dec 28;11:103-121. [Content Brief]

. H O Dyary, et al. Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb. Trop Biomed. 2019 Mar 1;36(1):94-102. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

海关编码	2934999090

1. 物质的识别

产品名：	Girinimbine
CAS号：	23095-44-5
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Girinimbine
分子式：
分子量：

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。