SETDB1-TTD-IN-1|cas:2755823-12-0|西域试剂

SETDB1-TTD-IN-1,99.61%

产品编号：Bellancom-141539| CAS NO：2755823-12-0| 分子式：C₂₈H₃₁N₅O₂| 分子量：469.58

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-141539		￥8200.00	杭州北京（现货）
Bellancom-141539		￥13200.00	杭州北京（现货）

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SETDB1-TTD-IN-1

产品介绍

SETDB1-TTD-IN-1 是一种有效，选择性和内源性结合剂竞争性的 SETDB1-TTD 抑制剂，K_d 值为 88 nM。SETDB1-TTD-IN-1 可用于 SETDB1-TTD 关联的生物学功能和疾病的研究。

生物活性

SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD), with a K_d of 88 nM. SETDB1-TTD-IN-1 can be used for the research of biological functions and disease associations of SETDB1-TTD.

体外研究

SETDB1-TTD-IN-1 shows some activity for 53BP1 and JMJD2A, with K_ds of 4.3 μM and 86 μM, respectively. SETDB1-TTD-IN-1 does not show activity against 14 of the 16 tested tudor domains (K_d>100 μM).
SETDB1-TTD-IN-1 (2.5-40 μM) efficiently and dose-dependently stabilizes the SETDB1-TTD protein in HEK293T cells.
SETDB1-TTD-IN-1 (2.5-40 μM; 24 h) significantly affected the expression of 72 genes in human acute monocytic leukemia THP-1 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (266.20 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1296 mL	10.6478 mL	21.2956 mL
5 mM	0.4259 mL	2.1296 mL	4.2591 mL
10 mM	0.2130 mL	1.0648 mL	2.1296 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献