ADU-S100 disodium salt MIW815 disodium salt; ML RR-S2 CDA disodium salt|cas:1638750-95-4|西域试剂

ADU-S100 disodium salt MIW815 disodium salt; ML RR-S2 CDA disodium salt

产品编号：Bellancom-12885A| CAS NO：1638750-95-4| 分子式：C₂₀H₂₂N₁₀Na₂O₁₀P₂S₂| 分子量：734.51

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货号	价格	库存与货期
Bellancom-12885A	￥3300.00	杭州北京（现货）
Bellancom-12885A	￥12000.00	杭州北京（现货）
Bellancom-12885A	￥20000.00	杭州北京（现货）

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ADU-S100 disodium salt MIW815 disodium salt; ML RR-S2 CDA disodium salt

产品介绍

ADU-S100 disodium salt (MIW815 disodium salt) 是干扰素基因刺激物的激活剂 (STING)，具有有效的抗肿瘤和免疫活性。

生物活性

ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulator of interferon genes (STING).

体外研究

ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING^REF and hSTING^Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8⁺ T cell responses, and improves long-term survival to 50%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 35 mg/mL (47.65 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3615 mL	6.8073 mL	13.6145 mL
5 mM	0.2723 mL	1.3615 mL	2.7229 mL
10 mM	0.1361 mL	0.6807 mL	1.3615 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶