Caracemide NSC-253272,95.0%
产品编号:Bellancom-119974| CAS NO:81424-67-1| 分子式:C6H11N3O4| 分子量:189.17
Caracemide (NSC-253272) 是一种衍生自异羟肟酸的新型抗癌药。Caracemide 通过底物结合位点的共价修饰使 R1 蛋白失活,并抑制大肠杆菌的核糖核苷酸还原酶。Caracemide 已显示出产生严重中枢神经系统 (CNS) 毒性。Caracemide 在体内会产生有毒的代谢产物甲基异氰酸酯 (MIC)。
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Caracemide NSC-253272
产品介绍 | Caracemide (NSC-253272) 可以抑制大肠杆菌的核糖核苷酸还原酶。Caracemide是衍生自异羟肟酸的新型抗癌药,会产生严重的中枢神经系统 (CNS) 毒性。 | ||||||||||||||||
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生物活性 | Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide is a novel anticancer agent derived from a hydroxamic acid and has demonstrated to produce severe central nervous system (CNS) toxicity. | ||||||||||||||||
体外研究 |
Caracemide inactivates R1 by covalent modification at the substrate-binding site and has a toxic metabolite, methylisocyanate (MIC), in vivo. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
体内研究 |
The mercapturic acid derivative AMCC was identified in urine rats following administration to rats of a single i.p. dose (6.6 mg/kg) of caracemide (NSC-253272). 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
体内研究 |
The mercapturic acid derivative AMCC was identified in urine rats following administration to rats of a single i.p. dose (6.6 mg/kg) of caracemide (NSC-253272). 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
性状 | Solid | ||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (528.63 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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参考文献 |
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