Sparstolonin B|cas:1259330-61-4|西域试剂

Sparstolonin B,99.54%

产品编号：Bellancom-116213| CAS NO：1259330-61-4| 分子式：C₁₅H₈O₅| 分子量：268.22

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货号	价格	库存与货期
Bellancom-116213	￥2100.00	杭州北京（现货）
Bellancom-116213	￥3500.00	杭州北京（现货）
Bellancom-116213	￥6500.00	杭州北京（现货）
Bellancom-116213	￥9800.00	杭州北京（现货）
Bellancom-116213	￥14700.00	杭州北京（现货）

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Sparstolonin B

产品介绍

Sparstolonin B 作为选择性 TLR2 和 TLR4 拮抗剂，选择性阻断 TLR2 和 TLR4 介导的炎症信号传导。Sparstolonin B 具有抗 HIV 和抗癌活性。

生物活性

Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.

体外研究

Sparstolonin B (1-20 µM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells.
Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2.
Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells
Concentration:	1 µM, 5 µM, 10 µM or 20 µM
Incubation Time:	2-4 days
Result:	Effectively and dose-dependently inhibits the viability of all neuroblastoma cell lines after 2 days (SH-SY5Y and IMR-32), 3 days (NGP cells) or 4 days (SKNF-1 and SK-N-BE(2) cells) treatment.

体内研究
(In Vivo)

Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5-6-week-old male C57Bl/6 mice (body weight 18-20 g)
Dosage:	100 μg/mouse
Administration:	I.p.
Result:	Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.

体内研究

Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5-6-week-old male C57Bl/6 mice (body weight 18-20 g)
Dosage:	100 μg/mouse
Administration:	I.p.
Result:	Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.

体内研究

Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5-6-week-old male C57Bl/6 mice (body weight 18-20 g)
Dosage:	100 μg/mouse
Administration:	I.p.
Result:	Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.

性状

Solid

溶解性数据

In Vitro:

DMSO : 10 mg/mL (37.28 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7283 mL	18.6414 mL	37.2828 mL
5 mM	0.7457 mL	3.7283 mL	7.4566 mL
10 mM	0.3728 mL	1.8641 mL	3.7283 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式