EC330|cas:2016795-77-8|西域试剂

EC330,99.60%

产品编号：Bellancom-100949| CAS NO：2016795-77-8| 分子式：C₃₀H₃₂F₂O₂| 分子量：462.57

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-100949	￥1000.00	杭州北京（现货）
Bellancom-100949	￥3000.00	杭州北京（现货）
Bellancom-100949	￥4300.00	杭州北京（现货）
Bellancom-100949	￥8000.00	杭州北京（现货）
Bellancom-100949	￥12000.00	杭州北京（现货）

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EC330

产品介绍

EC330是白血病抑制因子 (LIF) 抑制剂。

生物活性

EC330 is a leukemia inhibitory factor (LIF) inhibitor.

体外研究

EC330 shows marked specificity in MCF-7 cells overexpressing LIF verses MCF-7 cells. EC330 further shows cytoskeletal disruption and targeting cancer-associated fibroblasts (CAFs) through inhibition of alpha-SMA but not beta-tubulin.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

EC330 treatment (0.1, 0.5 and 2.5 mg/kg) dose dependently reduces tumor burden in ovarian (IGROV-1) and triple negative breast cancer (MDA-MB-231) cell xenografted mouse models as well as MDA-MB-231 PDX models. EC330 exhibits no reactivity towards thiol-cysteine residues, no off target binding to major receptors, kinases or ion channels. EC330 is orally bioavailable and found to be safe and tolerable in toxicity studies.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 20 mg/mL (43.24 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1618 mL	10.8092 mL	21.6183 mL
5 mM	0.4324 mL	2.1618 mL	4.3237 mL
10 mM	0.2162 mL	1.0809 mL	2.1618 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式