MFI8|cas:694488-83-0|西域试剂

MFI8,99.44%

产品编号：Bellancom-150031| CAS NO：694488-83-0| 分子式：C₁₆H₁₈ClNO| 分子量：275.77

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货号	价格	库存与货期
Bellancom-150031	￥2500.00	杭州北京（现货）
Bellancom-150031	￥4000.00	杭州北京（现货）
Bellancom-150031	￥8500.00	杭州北京（现货）
Bellancom-150031	￥13500.00	杭州北京（现货）

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MFI8

产品介绍

MFI8 是一种线粒体融合 (mitochondrial fusion) 的小分子抑制剂。

生物活性

MFI8 is a small molecule inhibitor of mitochondrial.

体外研究

MFI8 (20 μM; 6 h) reduces significantly mitochondrial aspect ratio with an EC₅₀ of 4.8 μM, and inhibits mitochondrial function via mitofusins and subsequently promoting mitochondrial fission.
MFI8 possesses functional groups that meet the criteria of the pharmacophore model to interact with mitofusins and promotes mitochondrial fission.
MFI8 binds to the HR2 domain of MFN2, modulates MFN conformation and complexes, and alters mitochondrial functionality.
MFI8 (0-20 μM; 6 h) concentration-responsively increases caspase-3/7 activity, induces cytochrome c release and decreases membrane potential in a mitofusin-dependent manner. MFI8 also induces DNA damage and induces cell death in combination with BV6 SMAC (second mitochondria-derived activator of caspases) mimetic.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (362.62 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6262 mL	18.1311 mL	36.2621 mL
5 mM	0.7252 mL	3.6262 mL	7.2524 mL
10 mM	0.3626 mL	1.8131 mL	3.6262 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献