Gadopentetic acid 钆喷酸; Gd-DTPA; gadolinium complex|cas:80529-93-7|西域试剂

Gadopentetic acid 钆喷酸; Gd-DTPA; gadolinium complex,99.0%

产品编号：Bellancom-107353| CAS NO：80529-93-7| 分子式：C₁₄H₂₀GdN₃O₁₀| 分子量：547.57

Gadopentetic acid (Gd-DTPA) 是顺磁性造影剂，通常通过静脉内注射 (i.v.) 的方式用于 DCE-MRI 研究。血浆中的 Gadopentetic acid (Gd-DTPA) 的初始浓度。([Gd-DTPA 0]) 是 DCE-MRI 的重要参数。 [Gd-DTPA 0] 与使用的注射剂量相关并且随受试者而变化。剂量0.025 mmol/kg Gd-DTPA 可缩短采集时间，减少受试者受用时间，半衰期为 37 mins，平均停留时间为 53.8 mins，AUC为 3.37 mmol/min/L。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-107353		￥500.00	杭州北京（现货）

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Gadopentetic acid 钆喷酸; Gd-DTPA; gadolinium complex

产品介绍

Gadopentetic acid (Gd-DTPA) 是一种顺磁性造影剂。Gadopentetic acid 在动态对比增强 MRI (DCE-MRI) 研究中，通常经静脉注射实施。Gadopentetic acid 还可用于肾源性系统性纤维化（NSF）的研究。

生物活性

Gadopentetic acid (Gd-DTPA) is a paramagnetic contrast agent. Gadopentetic acid commonly implemented by a bolus intravenous injection in Dynamic contrast-enhanced MRI (DCE-MRI) studies. Gadopentetic acid also can be used for the research of nephrogenic systemic fibrosis (NSF).

体外研究

体内研究

Gadopentetic acid (Gd-DTPA) (tail vein injection; 2 and 5mmol/kg; single) shows systematic metabolic responses involving changes in lipid metabolism, glucose metabolism, TCA cycle, amino acid metabolism and gut microbiota functions in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	rats
Dosage:	2 and 5mmol/kg
Administration:	tail vein injection, single
Result:	Observed urinary and serum metabonomic recovery but the metabolic effects of high-dosed (5mmol/kg) lasted long. Observed hyperlipidemia after Gd-DTPA injection.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	rats
Dosage:	2 and 5mmol/kg
Administration:	tail vein injection, single
Result:	Observed urinary and serum metabonomic recovery but the metabolic effects of high-dosed (5mmol/kg) lasted long. Observed hyperlipidemia after Gd-DTPA injection.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (182.63 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.83 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8263 mL	9.1313 mL	18.2625 mL
5 mM	0.3653 mL	1.8263 mL	3.6525 mL
10 mM	0.1826 mL	0.9131 mL	1.8263 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (182.63 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献

. Wan C, et al. Gd-DTPA-induced dynamic metabonomic changes in rat biofluids. Magn Reson Imaging. 2017 Dec;44:15-25. [Content Brief]

. Taheri S, et al. Analysis of pharmacokinetics of Gd-DTPA for dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Imaging. 2016 Sep;34(7):1034-40. [Content Brief]

化学品安全说明书(MSDS)

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产品编号(Item Number)

批号(Lot Number)

危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	26-37/39
WGK德国	3

Gadopentetic acid 钆喷酸; Gd-DTPA; gadolinium complex,99.0%

Gadopentetic acid 钆喷酸; Gd-DTPA; gadolinium complex

化学品安全说明书(MSDS)

质检证书(COA)

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