TDI-011536|cas:2687970-96-1|西域试剂

TDI-011536,99.38%

产品编号：Bellancom-150042| CAS NO：2687970-96-1| 分子式：C₁₉H₁₆N₄O₂S| 分子量：364.42

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-150042		￥5600.00	杭州北京（现货）
Bellancom-150042		￥9000.00	杭州北京（现货）

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TDI-011536

产品介绍

TDI-011536 是一种有效的 Lats 激酶抑制剂，能中断 Hippo-Yap 的信号传导，并可启动受损心肌细胞的增殖。TDI-011536 可用于研究器官的保护和再生。

生物活性

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.

体外研究

TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces proliferation of Müller glia in human retinal organoids.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	human retinal organoids
Concentration:	3 µM
Incubation Time:	24 h, 5 days
Result:	Supressed Yap phosphorylation and promoted Müller glia proliferation.

体内研究
(In Vivo)

TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs.
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection).
Dosage:	200 mg/kg
Administration:	Intraperitoneal injections; once.
Result:	Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.

Animal Model:	Male 8-week-old mice (cryolesion model).
Dosage:	100 mg/kg
Administration:	Intraperitoneal injections; once daily for 2 or 3 days.
Result:	Promoted cardiomyocytes proliferation.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection).
Dosage:	200 mg/kg
Administration:	Intraperitoneal injections; once.
Result:	Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.

Animal Model:	Male 8-week-old mice (cryolesion model).
Dosage:	100 mg/kg
Administration:	Intraperitoneal injections; once daily for 2 or 3 days.
Result:	Promoted cardiomyocytes proliferation.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection).
Dosage:	200 mg/kg
Administration:	Intraperitoneal injections; once.
Result:	Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.

Animal Model:	Male 8-week-old mice (cryolesion model).
Dosage:	100 mg/kg
Administration:	Intraperitoneal injections; once daily for 2 or 3 days.
Result:	Promoted cardiomyocytes proliferation.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (343.01 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7441 mL	13.7204 mL	27.4409 mL
5 mM	0.5488 mL	2.7441 mL	5.4882 mL
10 mM	0.2744 mL	1.3720 mL	2.7441 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式