PSI-697 P-Selectin Inhibitor|cas:851546-61-7|西域试剂

PSI-697 P-Selectin Inhibitor,99.73%

产品编号：Bellancom-15526| CAS NO：851546-61-7| 分子式：C₂₁H₁₈ClNO₃| 分子量：367.83

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货号	价格	库存与货期
Bellancom-15526	￥1400.00	杭州北京（现货）
Bellancom-15526	￥3500.00	杭州北京（现货）
Bellancom-15526	￥5000.00	杭州北京（现货）
Bellancom-15526	￥15000.00	杭州北京（现货）
Bellancom-15526	￥21000.00	杭州北京（现货）

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PSI-697 P-Selectin Inhibitor

产品介绍

PSI-697 是一种口服的 P-selectin 抑制剂，IC₅₀ 值为 125 μM。

生物活性

PSI-697 is an oral P-selectin inhibitor with an IC₅₀ of 125 μM.

体外研究

PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1, in a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM in vitro.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

PSI-697 (0-50 mg/kg; p.o.) significantly reduces the number of rolling leukocytes by 39% versus vehicle control.
PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to vehicle, without prolonging bleeding time in a rat venous thrombosis model.
PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis.
PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	4-5 weeks male Sprague-Dawley rat (50-100 g)
Dosage:	0 mg/kg, 30 mg/kg, 50 mg/kg
Administration:	Oral administration
Result:	At an oral dose of 50 mg/kg reduced the number of rolling leukocytes by 39% versus vehicle control.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	4-5 weeks male Sprague-Dawley rat (50-100 g)
Dosage:	0 mg/kg, 30 mg/kg, 50 mg/kg
Administration:	Oral administration
Result:	At an oral dose of 50 mg/kg reduced the number of rolling leukocytes by 39% versus vehicle control.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 45.8 mg/mL (124.51 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7186 mL	13.5932 mL	27.1865 mL
5 mM	0.5437 mL	2.7186 mL	5.4373 mL
10 mM	0.2719 mL	1.3593 mL	2.7186 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式