AG1024 Tyrphostin AG 1024,99.82%
产品编号:Bellancom-10253| CAS NO:65678-07-1| 分子式:C14H13BrN2O| 分子量:305.17
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AG1024 Tyrphostin AG 1024
产品介绍 | AG1024 (Tyrphostin AG 1024) 是一种可逆的,竞争性和选择性的胰岛素样生长因子-1 受体 (IGF-1R) 抑制剂,IC50 为 7 μM。AG1024 抑制胰岛素受体 (IR) 的磷酸化 (IC50=57 μM)。AG1024 诱导细胞凋亡 (apoptosis) 并具有抗癌活性。 | ||||||||||||||||||||||||
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生物活性 | AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity. | ||||||||||||||||||||||||
体外研究 |
AG1024 (Tyrphostin AG 1024; 2-10 μM; 1-5 days) shows a dose-dependent inhibition of cell proliferation. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay
Apoptosis Analysis
Western Blot Analysis
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体内研究 (In Vivo) |
AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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体内研究 |
AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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体内研究 |
AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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性状 | Solid | ||||||||||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : ≥ 50 mg/mL (163.84 mM) * "≥" means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百 *以上所有助溶剂都可在 西域 网站选购。
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 |
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参考文献 |
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