Amoscanate CGP4540|cas:26328-53-0|西域试剂

Amoscanate CGP4540,99.56%

产品编号：Bellancom-129051| CAS NO：26328-53-0| 分子式：C₁₃H₉N₃O₂S| 分子量：271.29

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Bellancom-129051	￥1600.00	杭州北京（现货）
Bellancom-129051	￥2500.00	杭州北京（现货）
Bellancom-129051	￥4800.00	杭州北京（现货）
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Amoscanate CGP4540

产品介绍

Amoscanate (CGP4540) 是苯基异硫氰酸酯，其中对位的氢被一个 4- 硝基苯胺基取代。Amoscanate 是一种抗血吸虫药。Amoscanate 作为一种异硫氰酸酯化合物和氧化磷酸化解耦剂，对鼠室管膜有明显的损伤作用。

生物活性

Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma.

体外研究

体内研究

Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain.
Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca⁺⁺-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum.
Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma.
Amoscanate elicits massive ultrastructural damage in ependymal cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats
Dosage:	500 mg/kg
Administration:	P.o.; 10 days
Result:	Destructed ependyma and periventricular brain.

Animal Model:	Sprague-Dawley rats
Dosage:	250 and 500 mg/kg
Administration:	P.o.; 28 days
Result:	Elicited necrosis, Ca⁺⁺-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum.

Animal Model:	Sprague-Dawley rats
Dosage:	25~500 mg/kg
Administration:	P.o.; 20 days
Result:	Elicited progressive necrosis of ependymal.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats
Dosage:	500 mg/kg
Administration:	P.o.; 10 days
Result:	Destructed ependyma and periventricular brain.

Animal Model:	Sprague-Dawley rats
Dosage:	250 and 500 mg/kg
Administration:	P.o.; 28 days
Result:	Elicited necrosis, Ca⁺⁺-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum.

Animal Model:	Sprague-Dawley rats
Dosage:	25~500 mg/kg
Administration:	P.o.; 20 days
Result:	Elicited progressive necrosis of ependymal.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (184.30 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6861 mL	18.4305 mL	36.8609 mL
5 mM	0.7372 mL	3.6861 mL	7.3722 mL
10 mM	0.3686 mL	1.8430 mL	3.6861 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Johanson C, et al. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011;39(1):186-212. [Content Brief]

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