Ro 10-5824 dihydrochloride|cas:189744-94-3|西域试剂

Ro 10-5824 dihydrochloride,99.93%

产品编号：Bellancom-101384A| CAS NO：189744-94-3| 分子式：C₁₇H₂₂Cl₂N₄| 分子量：353.29

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-101384A		￥800.00	杭州北京（现货）
Bellancom-101384A		￥1200.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Ro 10-5824 dihydrochloride

产品介绍

Ro 10-5824 dihydrochloride 是一种选择性的 dopamine D4 受体 部分激动剂，K_i 值为 5.2 nM。

生物活性

Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with K_i of 5.2 nM.

体外研究

RO-10-5824 shows high affinity binding with a K_i=5.2±0.9 nM (n=3), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates ³⁵S-GTPγS binding with an EC₅₀ value of 205±67 nM (n=7) and maximal induction at 36±4% above basal level.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Ro 10-5824 (3 mg/kg) increases the success rate in the ORD task. At doses of 1 and 3 mg/kg, Ro 10-5824 increases baseline gamma band activity in the frontal cortex. Ro 10-5824 has no effect on spontaneous locomotion. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (283.05 mM; Need ultrasonic)

DMSO : 8.33 mg/mL (23.58 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8305 mL	14.1527 mL	28.3054 mL
5 mM	0.5661 mL	2.8305 mL	5.6611 mL
10 mM	0.2831 mL	1.4153 mL	2.8305 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶