SPHINX|cas:848057-98-7|西域试剂

SPHINX,99.87%

产品编号：Bellancom-132126| CAS NO：848057-98-7| 分子式：C₁₇H₁₇F₃N₂O₃| 分子量：354.32

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货号	价格	库存与货期
Bellancom-132126	￥2800.00	杭州北京（现货）
Bellancom-132126	￥4200.00	杭州北京（现货）
Bellancom-132126	￥7800.00	杭州北京（现货）
Bellancom-132126	￥12500.00	杭州北京（现货）

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SPHINX

产品介绍

SPHINX 是 SRPK1 的选择性抑制剂，IC₅₀ 值为 0.58 μM。SPHINX 有效地减少体内脉络膜新生血管 (CNV)。SPHINX 可用于老年性黄斑变性的研究。

生物活性

SPHINX is a selective SRPK1 inhibitor with an IC₅₀ value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD.

体外研究

SPHINX (10 μM; 2 h) affects EGF-induced phosphorylation of SRSF1 and SRSF2.
SPHINX (5 μM; 24 h) reduces the expression of VEGF165 relative to GAPDH control either in primary RPE and ARPE-19 cell lines.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	ARPE-19 cell line
Concentration:	10 μM
Incubation Time:	2 hours
Result:	Blocked EGF-induced phosphorylation of SRSF1 and SRSF2.

体内研究
(In Vivo)

SPHINX (10 ng; i.o. on laser photocoagulation day 0 and day 7) affects neovascular growth in vivo.
SPHINX (25 ng; i.o. on laser photocoagulation day 0 and day 7) affects the CNV area in CNV rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57/B6 mice with laser-induced CNV
Dosage:	10 ng
Administration:	Intraocular injection; 10 ng on laser photocoagulation day 0 and day 7
Result:	Significantly reduced neovascular growth compared with saline-injected controls.

Animal Model:	Norway Brown rats with laser-induced choroidal neovascularization
Dosage:	25 ng (10 ng/uL)
Administration:	Intraocular injection; 25 ng (10 ng/uL) on laser photocoagulation day 0 and day 7
Result:	Significantly reduced the CNV area compared with saline injected controls.

体内研究

SPHINX (10 ng; i.o. on laser photocoagulation day 0 and day 7) affects neovascular growth in vivo.
SPHINX (25 ng; i.o. on laser photocoagulation day 0 and day 7) affects the CNV area in CNV rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57/B6 mice with laser-induced CNV
Dosage:	10 ng
Administration:	Intraocular injection; 10 ng on laser photocoagulation day 0 and day 7
Result:	Significantly reduced neovascular growth compared with saline-injected controls.

Animal Model:	Norway Brown rats with laser-induced choroidal neovascularization
Dosage:	25 ng (10 ng/uL)
Administration:	Intraocular injection; 25 ng (10 ng/uL) on laser photocoagulation day 0 and day 7
Result:	Significantly reduced the CNV area compared with saline injected controls.

体内研究

SPHINX (10 ng; i.o. on laser photocoagulation day 0 and day 7) affects neovascular growth in vivo.
SPHINX (25 ng; i.o. on laser photocoagulation day 0 and day 7) affects the CNV area in CNV rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57/B6 mice with laser-induced CNV
Dosage:	10 ng
Administration:	Intraocular injection; 10 ng on laser photocoagulation day 0 and day 7
Result:	Significantly reduced neovascular growth compared with saline-injected controls.

Animal Model:	Norway Brown rats with laser-induced choroidal neovascularization
Dosage:	25 ng (10 ng/uL)
Administration:	Intraocular injection; 25 ng (10 ng/uL) on laser photocoagulation day 0 and day 7
Result:	Significantly reduced the CNV area compared with saline injected controls.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (141.12 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8223 mL	14.1115 mL	28.2231 mL
5 mM	0.5645 mL	2.8223 mL	5.6446 mL
10 mM	0.2822 mL	1.4112 mL	2.8223 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式