RPH-2823, a basic triamterene derivative, induces a dose-dependent decrease in short-circuit current (SCC) and increase in transepithelial electrical resistance.

RPH-2823 influences transepithelial Na⁺ transport by interacting with the Na⁺ channel or a regulator site of it within the apical membrane.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Kipnowski J, et al. Effects of standard diuretics and RPH 2823 on transepithelial Na+ transport in isolated frog skin. Klin Wochenschr. 1986;64(16):750-759.  [Content Brief]

  . Priewer H, et al. Pharmacodynamics and pharmacokinetics of the basic triamterene analogue dimethylaminohydroxypropoxytriamterene. Arzneimittelforschung. 1985;35(11):1688-1691.  [Content Brief]