BRD7116|cas:329059-55-4|西域试剂

BRD7116,99.73%

产品编号：Bellancom-18714| CAS NO：329059-55-4| 分子式：C₂₈H₃₆N₂O₄S| 分子量：496.66

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货号	价格	库存与货期
Bellancom-18714	￥700.00	杭州北京（现货）
Bellancom-18714	￥900.00	杭州北京（现货）
Bellancom-18714	￥3500.00	杭州北京（现货）

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BRD7116

产品介绍

BRD7116竞争性地结合到细菌DNA促旋酶, 作用于LSCe 细胞，EC50值为200 nM, 具有非自治性的抗白血病活性。

生物活性

BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity. IC50 value: 200 nM (EC50, for LSCe cells) Target: DNA gyrase BRD7116 is a bis-aryl sulfone, shows evidence of stroma-mediated anti-LSCe activity. BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture, whereas it displays limited activity against normal HSPCs and AML cell lines (~50% inhibition at 20 μM). BRD7116 also shows activity against patient-derived, primary human leukemia cells. BRD7116 inhibits LSCs via non-cell-autonomous effects on stromal cells as well as cell-autonomous induction of myeloid differentiation genes in LSCs.

体外研究

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 48 mg/mL (96.65 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0134 mL	10.0672 mL	20.1345 mL
5 mM	0.4027 mL	2.0134 mL	4.0269 mL
10 mM	0.2013 mL	1.0067 mL	2.0134 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式