Mivotilate YH439|cas:130112-42-4|西域试剂

Mivotilate YH439,99.58%

产品编号：Bellancom-100242| CAS NO：130112-42-4| 分子式：C₁₂H₁₄N₂O₃S₃| 分子量：330.45

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货号	价格	库存与货期
Bellancom-100242	￥3000.00	杭州北京（现货）
Bellancom-100242	￥4800.00	杭州北京（现货）
Bellancom-100242	￥9500.00	杭州北京（现货）
Bellancom-100242	￥14500.00	杭州北京（现货）

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Mivotilate YH439

产品介绍

Mivotilate 是一种非毒性的，有效的芳烃受体 (aryl hydrocarbon receptor) 激动剂，具有护肝作用。

生物活性

Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.

体外研究

Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor. Mivotilate (YH439) has a novel activation mode that tolerates mutation of histidine 285 to tyrosine. Mivotilate induces cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Mivotilate (YH439, 150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats, but shows no obvious effect on NADPH-dependent P450 oxidoreductase activity. Mivotilate (75-300 mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 12.5 mg/mL (37.83 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0262 mL	15.1309 mL	30.2618 mL
5 mM	0.6052 mL	3.0262 mL	6.0524 mL
10 mM	0.3026 mL	1.5131 mL	3.0262 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式