0990CL,98.0%
产品编号:Bellancom-102076| CAS NO:511514-03-7| 分子式:C21H21N5| 分子量:343.42
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0990CL
产品介绍 | 0990CL 是能够与 Gαi 直接相互作用的,异源三聚体 Gαi subunit 特异性抑制剂。0990CL 能够阻断 α2AR 介导的 cAMP 调节。 | ||||||||||||||||
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生物活性 | 0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP. | ||||||||||||||||
体外研究 |
0990CL (100 nM-1 μM; 24 hours) is able to restore α2AR/Gαi mediated cAMP levels elicited by Fsk and UK14304 in HEK293 GloSensor cells. When the dosage is at 100 nM, it restores 31% of the reduction of cAMP.0990CL (30 μM; pre-treatment 30mins) shows selectivity for Gαi1 over Gαq. It demonstrates selectivity for Gαi and Gαq and results in a maximum endpoint fluorescence reduction of 38±8% and 10%, respectively. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
体内研究 | |||||||||||||||||
体内研究 | |||||||||||||||||
性状 | Solid | ||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (145.59 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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参考文献 |