PTPN22-IN-1|cas:2580935-57-3|西域试剂

PTPN22-IN-1,98.01%

产品编号：Bellancom-139693| CAS NO：2580935-57-3| 分子式：C₂₆H₂₁N₃O₅| 分子量：455.46

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货号	价格	库存与货期
Bellancom-139693	￥4000.00	杭州北京（现货）
Bellancom-139693	￥6800.00	杭州北京（现货）
Bellancom-139693	￥13500.00	杭州北京（现货）

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PTPN22-IN-1

产品介绍

PTPN22-IN-1 是一种有效的 PTPN22 抑制剂 (IC₅₀=1.4 µM; K_i=0.50 µM)。PTPN22-IN-1 对 PTPN22 的选择性是类似磷酸酶的 7-10 倍。PTPN22-IN-1 增强体内抗肿瘤免疫反应。

生物活性

PTPN22-IN-1 is a potent PTPN22 inhibitor (IC₅₀=1.4 µM; K_i=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses. From WO2021007491A1 compound L-1.

体外研究

PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects.
Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 µM h and C_max of 1.1 1 µM (Fig. 9d), which is more than twice of its K_i value.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

运输条件

Room temperature in continental US; may vary elsewhere.