MS023 dihydrochloride,99.78%
产品编号:Bellancom-19615B| CAS NO:1992047-64-9| 分子式:C17H27Cl2N3O| 分子量:360.32
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MS023 dihydrochloride
产品介绍 | MS023 dihydrochloride 是一种有效选择性的,具有细胞活性的人 I 型蛋白精氨酸甲基转移酶 (PRMTs) 抑制剂,对 PRMT1,PRMT3,PRMT4,PRMT6 和 PRMT8 的 IC50 分别为 30,119,83,4 和 5 nM。 | ||||||||||||||||
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生物活性 | MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively. | ||||||||||||||||
体外研究 |
MS023 (1-1000 nM; 48 hours) inhibits PRMT1 methyltransferase activity in MCF7 cells. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis
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体内研究 (In Vivo) |
Administration of MS023 (160 mg/kg, i.p) in combination with PKC412 (100 mg/kg, i.g.) blocks MLL-r acute lymphoblastic leukemia (ALL) propagation by inhibiting maintenance of functional MLL-r ALL-initiating cells. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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体内研究 |
Administration of MS023 (160 mg/kg, i.p) in combination with PKC412 (100 mg/kg, i.g.) blocks MLL-r acute lymphoblastic leukemia (ALL) propagation by inhibiting maintenance of functional MLL-r ALL-initiating cells. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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体内研究 |
Administration of MS023 (160 mg/kg, i.p) in combination with PKC412 (100 mg/kg, i.g.) blocks MLL-r acute lymphoblastic leukemia (ALL) propagation by inhibiting maintenance of functional MLL-r ALL-initiating cells. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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性状 | Solid | ||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : ≥ 150 mg/mL (416.30 mM) H2O : 33.33 mg/mL (92.50 mM; Need ultrasonic) * "≥" means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在 西域 网站选购。
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) | ||||||||||||||||
参考文献 |
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