CP-10|cas:2366268-80-4|西域试剂

CP-10,98.22%

产品编号：Bellancom-125835| CAS NO：2366268-80-4| 分子式：C₄₄H₄₉N₁₃O₇| 分子量：871.94

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货号	价格	库存与货期
Bellancom-125835	￥8800.00	杭州北京（现货）
Bellancom-125835	￥12500.00	杭州北京（现货）
Bellancom-125835	￥26500.00	杭州北京（现货）

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CP-10

产品介绍

CP-10 是由Cereblon配体和CDK配体相连的PROTAC，具有高选择性，特异性和显著的 CDK6 降解潜力 (DC₅₀=2.1 nM) 的 PROTAC。它抑制几种造血细胞癌的增殖，包括多发性骨髓瘤，并且对突变和过表达的 CDK6 仍然可以降解。

生物活性

CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC₅₀=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6.

体外研究

CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM in human glioblastoma U251 cells. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC₅₀: 50-80 fold).
CP-10 displays a cell inhibition potential in multiple myeloma cell MM.1S (IC₅₀≈10 nM) and mantle cell lymphoma cells (in Mino, IC₅₀≈8 nM).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 200 mg/mL (229.37 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.1469 mL	5.7343 mL	11.4687 mL
5 mM	0.2294 mL	1.1469 mL	2.2937 mL
10 mM	0.1147 mL	0.5734 mL	1.1469 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献