L-798106 CM9; GW671021|cas:244101-02-8|西域试剂

L-798106 CM9; GW671021,99.85%

产品编号：Bellancom-15274| CAS NO：244101-02-8| 分子式：C₂₇H₂₂BrNO₄S| 分子量：536.44

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货号	价格	库存与货期
Bellancom-15274	￥1560.00	杭州北京（现货）
Bellancom-15274	￥2496.00	杭州北京（现货）
Bellancom-15274	￥5460.00	杭州北京（现货）
Bellancom-15274	￥8775.00	杭州北京（现货）
Bellancom-15274	￥14040.00	杭州北京（现货）

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L-798106 CM9; GW671021

产品介绍

L-798106 是强效且高度选择性的前列腺素类 EP₃ 受体拮抗剂 (K_i=0.3 nM)，它在 EP4，EP1 和 EP2 受体上也具有微摩尔活性，K_i 值分别为 916 nM，>5000 nM 和 >5000 nM。

生物活性

L-798106 is potent and highly selective prostanoid EP₃ receptor antagonist (K_i=0.3 nM), it also has micromolar activities at the EP₄, EP₁ and EP₂ receptors with K_i values of 916 nM, >5000 nM and >5000 nM, respectively.

体外研究

L-798106 (200 nM) inhibits electrical field stimulation-induced contractile responses.
L-798106 (10 μM) inhibits electrical field stimulation-evoked ACh release.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Guinea-pig vas deferens
Concentration:	200 nM
Incubation Time:
Result:	Showed an apparent pA2 of 7.48±0.25.

Cell Viability Assay

Cell Line:	Guinea-pig tracheal smooth muscle
Concentration:	10 μM
Incubation Time:
Result:	Attenuated significantly the inhibitory effect of all agents tested (in % inhibition of EFS-induced release: 8-iso-PGE1 from 56.9 to 8.6; 8-iso-PGE2 from 51.6 to 9.2; PGE2 from 61.2 to 2.9; sulprostone from 55.9 to 18.8).

体内研究
(In Vivo)

L-798106 (oral gavage; 50 and 100 μg/kg; once daily; 8 w) suppresses systemic insulin resistance and AT inflammation in db/db mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male db/db mice
Dosage:	50 and 100 μg/kg
Administration:	Oral gavage; 50 and 100 μg/kg; once daily; 8 weeks
Result:	Suppressed the increased fasting blood glucose levels in the db/db mice. Suppressed increased proinflammatory gene expressions in the adipocytes isolated from the epididymal AT of the db/db mice.

体内研究

L-798106 (oral gavage; 50 and 100 μg/kg; once daily; 8 w) suppresses systemic insulin resistance and AT inflammation in db/db mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male db/db mice
Dosage:	50 and 100 μg/kg
Administration:	Oral gavage; 50 and 100 μg/kg; once daily; 8 weeks
Result:	Suppressed the increased fasting blood glucose levels in the db/db mice. Suppressed increased proinflammatory gene expressions in the adipocytes isolated from the epididymal AT of the db/db mice.

体内研究

L-798106 (oral gavage; 50 and 100 μg/kg; once daily; 8 w) suppresses systemic insulin resistance and AT inflammation in db/db mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male db/db mice
Dosage:	50 and 100 μg/kg
Administration:	Oral gavage; 50 and 100 μg/kg; once daily; 8 weeks
Result:	Suppressed the increased fasting blood glucose levels in the db/db mice. Suppressed increased proinflammatory gene expressions in the adipocytes isolated from the epididymal AT of the db/db mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 10 mg/mL (18.64 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8641 mL	9.3207 mL	18.6414 mL
5 mM	0.3728 mL	1.8641 mL	3.7283 mL
10 mM	0.1864 mL	0.9321 mL	1.8641 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式