BpV(HOpic)|cas:722494-26-0|西域试剂

BpV(HOpic),95.0%

产品编号：Bellancom-128693| CAS NO：722494-26-0| 分子式：C₆H₄K₂NO₈V| 分子量：347.24

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-128693		￥2700.00	杭州北京（现货）

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BpV(HOpic)

产品介绍

BpV(HOpic) 是一种有效的和选择性的 PTEN 抑制剂，IC₅₀ 值为 14 nM。Nanocarrier-BpV(HOpic) 具有神经保护作用。

生物活性

BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC₅₀ of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity.

体外研究

BpV(HOpic) (1 µM) treatment increases cell proliferation and decreases apoptotic rate in MG63 cells received Cisplatin treatment.
Bpv(HOpic) (1 µM) enhances migration of C2C12 myoblasts and is associated with activation of PI3K/AKT and MAPK/ERK signalling pathways^[4].
BpV(HOpic) (1 µM; 48 hours) promotes the initiation of swine follicle growth and development, similar as in rodent species and humans^[5].
Nanocarrier-BpV(HOpic) enhances axonal outgrowth of neurons.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

BpV(HOpic) (0.05 mg/kg; i.p.) at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury in vivo^[6].
BpV(HOpic) (200 μg/kg; i.p.) exacerbates renal dysfunction and promotes tubular damage in mice with ischemia/reperfusion injury (IRI)^[7].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats are subjected to partial hepatic ischemia^[6]
Dosage:	0.05 mg/kg
Administration:	I.p. injections at the start of reperfusion
Result:	Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation.

Animal Model:	Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia^[7]
Dosage:	200 μg/kg
Administration:	I.p. injections 1 h before ischemia and then administers every 6 h after ischemia for 24 hr
Result:	Raised the level of serum creatinine and blood serum urea nitrogen.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats are subjected to partial hepatic ischemia^[6]
Dosage:	0.05 mg/kg
Administration:	I.p. injections at the start of reperfusion
Result:	Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation.

Animal Model:	Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia^[7]
Dosage:	200 μg/kg
Administration:	I.p. injections 1 h before ischemia and then administers every 6 h after ischemia for 24 hr
Result:	Raised the level of serum creatinine and blood serum urea nitrogen.