LDV, a tripeptide, is a non-fluorescent analog of LDV-FITC. LDV is a α4β1 integrin (VLA-4) ligand, and binds α4β1 integrin in leukemia cells.

An LDV small molecule is well-characterized VLA-4 ligand that has been used to detect VLA-4 affinity and conformational changes. LDV is the minimum sequence of the CS-1 region of fibronectin necessary to bind α4β1 integrin.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Ben H Njus, et al. Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev Technol. 2009 Oct;7(5):507-15.  [Content Brief]

  . Estelle Gérard, et al. LDV peptidomimetics equipped with biotinylated spacer-arms: synthesis and biological evaluation on CCRF-CEM cell line. Bioorg Med Chem Lett. 2012 Jan 1;22(1):586-90.  [Content Brief]