Kdo2-Lipid A ammonium|cas:1246298-62-3|西域试剂

Kdo2-Lipid A ammonium,95.0%

产品编号：Bellancom-N8277| CAS NO：1246298-62-3| 分子式：C₁₁₀H₂₁₄N₆O₃₉P₂| 分子量：2306.84

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N8277		￥4890.00	杭州北京（现货）

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Kdo2-Lipid A ammonium

产品介绍

Kdo2-Lipid A ammonium 是一种化学定义的脂多糖 (LPS) ，其内毒素活性等同于 LPS。Kdo2-Lipid A ammonium 对 TLR4 具有高度选择性。Kdo2-Lipid A ammonium 刺激 TNF 和 PGE2 的释放。

生物活性

Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2.

体外研究

Kdo2-Lipid A (1 µM) stimulates the release of both TNF and PGE2 from the adult rat spinal astrocytes cell cultures.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR

Cell Line:	TNF and PGE2
Concentration:	1 µM
Incubation Time:
Result:	Amounts of protein (mg) is 6.2 ± 0.6 ng/mL and 1.4 ± 0.3 ng/mL for TNF and PGE2.

体内研究
(In Vivo)

KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats (Male Holzman Sprague-Dawley, 300–400 g)
Dosage:	0.1 to 10 µg
Administration:	I.T.; 0.1-10 µg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
Result:	Intrathecal injection of 1 µg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.

体内研究

KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats (Male Holzman Sprague-Dawley, 300–400 g)
Dosage:	0.1 to 10 µg
Administration:	I.T.; 0.1-10 µg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
Result:	Intrathecal injection of 1 µg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.

体内研究

KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats (Male Holzman Sprague-Dawley, 300–400 g)
Dosage:	0.1 to 10 µg
Administration:	I.T.; 0.1-10 µg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
Result:	Intrathecal injection of 1 µg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.