PHPS1|cas:314291-83-3|西域试剂

PHPS1,99.97%

产品编号：Bellancom-112368| CAS NO：314291-83-3| 分子式：C₂₁H₁₅N₅O₆S| 分子量：465.44

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货号	价格	库存与货期
Bellancom-112368	￥1300.00	杭州北京（现货）
Bellancom-112368	￥2100.00	杭州北京（现货）
Bellancom-112368	￥4400.00	杭州北京（现货）
Bellancom-112368	￥7100.00	杭州北京（现货）
Bellancom-112368	￥11500.00	杭州北京（现货）

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PHPS1

产品介绍

PHPS1 是一种有效的选择性 Shp2 抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的 K_i 值分别为 0.73，5.8，10.7，5.8 和 0.47 μM。

生物活性

PHPS1 is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively.

体外研究

PHPS1 (30 μM; 6 days) inhibits proliferation of human tumor cells.
PHPS1 (5-20 μM; 5-360 minutes) inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Human cancer cell lines MDA-MB-435, HCT-116 (colon carcinoma), HCT-15 (colon carcinoma), PC-3 (prostate carcinoma) HT-29 (colon carcinoma), NCI-H661 (lung carcinoma), and Caki-1 (kidney carcinoma)
Concentration:	30 μM
Incubation Time:	6 days
Result:	Resulted in a reduction in cell number of between 0% (Caki-1) to 74% (HT-29).

Western Blot Analysis

Cell Line:	Madin-Darby canine kidney (MDCK) cells
Concentration:	5, 10, 20 μM
Incubation Time:	5, 15, 60, 120, 360 minutes
Result:	Inhibited HGF/SF (1 unit/mL)-induced phosphorylation and thus activation of Erk1/2 over a time period of 15 min to 6 h. In contrast, transient phosphorylation of Erk1/2 after 5 min was not affected. Exhibited no effect on HGF/SF-induced activation of PI3K/Akt or Stat3.

体内研究
(In Vivo)

PHPS1 (3 mg/kg; i.p. injection; every day during the last week on the high-fat diet) renders Ldlr^-/- mice less susceptible to atherosclerosis development.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Ldlr^-/- (005061) mice
Dosage:	3 mg/kg
Administration:	Intraperitoneal (i.p.) injection; every day during the last week on the high-fat diet.
Result:	Revealed a significant decrease in atherosclerotic plaque size in the aorta compared with the other two groups.

体内研究

PHPS1 (3 mg/kg; i.p. injection; every day during the last week on the high-fat diet) renders Ldlr^-/- mice less susceptible to atherosclerosis development.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Ldlr^-/- (005061) mice
Dosage:	3 mg/kg
Administration:	Intraperitoneal (i.p.) injection; every day during the last week on the high-fat diet.
Result:	Revealed a significant decrease in atherosclerotic plaque size in the aorta compared with the other two groups.

体内研究

PHPS1 (3 mg/kg; i.p. injection; every day during the last week on the high-fat diet) renders Ldlr^-/- mice less susceptible to atherosclerosis development.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Ldlr^-/- (005061) mice
Dosage:	3 mg/kg
Administration:	Intraperitoneal (i.p.) injection; every day during the last week on the high-fat diet.
Result:	Revealed a significant decrease in atherosclerotic plaque size in the aorta compared with the other two groups.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (53.71 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1485 mL	10.7425 mL	21.4850 mL
5 mM	0.4297 mL	2.1485 mL	4.2970 mL
10 mM	0.2149 mL	1.0743 mL	2.1485 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献