STAT3-IN-3|cas:2361304-26-7|西域试剂

STAT3-IN-3,98.23%

产品编号：Bellancom-128588| CAS NO：2361304-26-7| 分子式：C₂₇H₂₆BrN₃O₆S| 分子量：600.48

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货号	价格	库存与货期
Bellancom-128588	￥3500.00	杭州北京（现货）
Bellancom-128588	￥5500.00	杭州北京（现货）
Bellancom-128588	￥11000.00	杭州北京（现货）
Bellancom-128588	￥19500.00	杭州北京（现货）
Bellancom-128588	￥35000.00	杭州北京（现货）

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STAT3-IN-3

产品介绍

STAT3-IN-3 是一种有效和选择性的 STAT3 抑制剂，有抗增殖活性。STAT3-IN-3 可以引起乳腺癌细胞凋亡 (apoptosis)。STAT3-IN-3 是有前途的靶向线粒体的 STAT3 抑制剂，能用于癌症的研究。

生物活性

STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research.

体外研究

STAT3-IN-3 has no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2.
STAT3-IN-3 inhibits the growth of MDA-MB-231, HCT-116, HepG2, and MCF-7 cells with IC₅₀s of 1.43 μM, 1.89 μM, 2.88 μM, and 3.33 μM, respectively.
STAT3-IN-3 down-regulates the expression of STAT3 target genes Bcl-2 and Cyclin D1.
STAT3-IN-3 inhibits STAT3 tyrosine phosphorylation and serine phosphorylation.
STAT3-IN-3 inhibits STAT3 DNA-binding activity.
STAT3-IN-3 (1-4 μM; 24 hours) increases ROS production and remarkably reduces the mitochondrial membrane potential to induce mitochondrial apoptotic pathway.
STAT3-IN-3 (1-4 μM; 24 hours) can induce the cleavage of caspase-9, caspase-3 and PARP.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	MDA-MB-231 cells, HCT-116 cells, HepG2 cells, MCF-7cells
Concentration:	MTT assay
Incubation Time:	48 hours
Result:	Exhibited anti-proliferative activity.

Apoptosis Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	0 μM, 1 μM, 2 μM, 4 μM
Incubation Time:	24 hours
Result:	Induced the apoptosis of MDA-MB-231 cells dose-dependently and the apoptosis rates.

Western Blot Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	0 μM, 1 μM, 2 μM, 4 μM
Incubation Time:	24 hours
Result:	Induced the cleavage of caspase-9, caspase-3 and PARP.

体内研究
(In Vivo)

STAT3-IN-3 (10mg/kg-20 mg/kg; i.p.; daily; for 14 days) possesses potent antitumor activity against implanted 4T1 breast tumors growth.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult female BALB/c mice (6 weeks of age)
Dosage:	10 mg/kg, 20 mg/kg
Administration:	Intraperitoneal injection, daily, for 14 days
Result:	Significantly inhibited tumor volume.

体内研究

STAT3-IN-3 (10mg/kg-20 mg/kg; i.p.; daily; for 14 days) possesses potent antitumor activity against implanted 4T1 breast tumors growth.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult female BALB/c mice (6 weeks of age)
Dosage:	10 mg/kg, 20 mg/kg
Administration:	Intraperitoneal injection, daily, for 14 days
Result:	Significantly inhibited tumor volume.

体内研究

STAT3-IN-3 (10mg/kg-20 mg/kg; i.p.; daily; for 14 days) possesses potent antitumor activity against implanted 4T1 breast tumors growth.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult female BALB/c mice (6 weeks of age)
Dosage:	10 mg/kg, 20 mg/kg
Administration:	Intraperitoneal injection, daily, for 14 days
Result:	Significantly inhibited tumor volume.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (8.33 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6653 mL	8.3267 mL	16.6533 mL
5 mM	0.3331 mL	1.6653 mL	3.3307 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式