Ubiquitin Isopeptidase Inhibitor I, G5 NSC144303,98.0%
产品编号：Bellancom-100738| CAS NO：108477-18-5| 分子式：C19H14N2O7S| 分子量：414.39
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，
Ubiquitin Isopeptidase Inhibitor I, G5 NSC144303
| 产品介绍 | Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依赖的半胱天冬酶和细胞凋亡的激活剂，对E1A和E1A/C9DN细胞的IC50值分别为1.76和1.6 μM。 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 生物活性 | Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. | ||||||||||||||||
| 体外研究 |
G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC50s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
| 体内研究 | |||||||||||||||||
| 体内研究 | |||||||||||||||||
| 性状 | Solid | ||||||||||||||||
| 溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (120.66 mM; Need ultrasonic) THF : 3.44 mg/mL (8.30 mM; Need ultrasonic) Acetone : 2.86 mg/mL (6.90 mM; Need ultrasonic) Ethanol : < 1 mg/mL (ultrasonic) (insoluble) 配制储备液
*
请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。 | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 储存方式 |
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。 | ||||||||||||||||
| 参考文献 |
浙公网安备 33010802013016号