SU0268|cas:2210228-45-6|西域试剂

SU0268,99.84%

产品编号：Bellancom-139056| CAS NO：2210228-45-6| 分子式：C₂₆H₂₅N₃O₄S| 分子量：475.56

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-139056	￥1300.00	杭州北京（现货）
Bellancom-139056	￥2100.00	杭州北京（现货）
Bellancom-139056	￥4200.00	杭州北京（现货）
Bellancom-139056	￥6700.00	杭州北京（现货）
Bellancom-139056	￥9800.00	杭州北京（现货）

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SU0268

产品介绍

SU0268 是有效的、特异性的 8-8-氧鸟嘌呤 DNA 糖基化酶1 (OGG1) 的抑制剂。SU0268 可调控铜绿假单胞杆菌感染的免疫反应。

生物活性

SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.

体外研究

MTH1-depleted cells are less sensitive to the OGG1-specific inhibitor, SU0268 (5-10 μM), than their control shGFP counterparts.
SU0268/IACS-4759 (5-20 μM, 48h) co-treated cells are more viable than the correspondingly-treated IACS-4759- or SU0268-treated cells.
SU0268 does not bind DNA and thus interacts with OGG1 specifically rather than its substrate.
SU0268 induces the release of type I IFN by the mitochondrial DNA-cGAS-STING-IRF3-IFN-β axis, which decreases bacterial loads and halts disease progression.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	A549 shGFP and shMTH1 (2000 cells per well).
Concentration:	0.1 μM, 0.5 μM, 1 μM, 2.5 μM, 5 μM, 7.5 μM, 10 μM.
Incubation Time:	24 or 48 h.
Result:	The shGFP cells were more susceptible to OGG1 inhibition via increasing SU0268 doses than the shMTH1 cells, especially at the 48 time-point.

体内研究
(In Vivo)

SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment in MH-S cells and C57BL/6N mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Anesthetized C57BL/6N mice.
Dosage:	10 mg/kg.
Administration:	Intranasally treated.
Result:	Significantly inhibits inflammatory responses and mitigates P. aeruginosa infection.

体内研究

SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment in MH-S cells and C57BL/6N mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Anesthetized C57BL/6N mice.
Dosage:	10 mg/kg.
Administration:	Intranasally treated.
Result:	Significantly inhibits inflammatory responses and mitigates P. aeruginosa infection.

体内研究

SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment in MH-S cells and C57BL/6N mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Anesthetized C57BL/6N mice.
Dosage:	10 mg/kg.
Administration:	Intranasally treated.
Result:	Significantly inhibits inflammatory responses and mitigates P. aeruginosa infection.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (210.28 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1028 mL	10.5139 mL	21.0278 mL
5 mM	0.4206 mL	2.1028 mL	4.2056 mL
10 mM	0.2103 mL	1.0514 mL	2.1028 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.26 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.26 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.26 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。