RHPS4|cas:390362-78-4|西域试剂

RHPS4,98.62%

产品编号：Bellancom-101089| CAS NO：390362-78-4| 分子式：C₂₃H₂₀F₂N₂O₄S| 分子量：458.48

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货号	价格	库存与货期
Bellancom-101089	￥750.00	杭州北京（现货）
Bellancom-101089	￥1200.00	杭州北京（现货）
Bellancom-101089	￥2400.00	杭州北京（现货）
Bellancom-101089	￥4000.00	杭州北京（现货）

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RHPS4

产品介绍

RHPS4 是有效的端粒酶 (telomerase) 抑制剂 (IC₅₀ = 0.33 μM)。RHPS4 是 DNA 损伤的诱导剂。

生物活性

RHPS4 is a potent telomerase inhibitor (IC₅₀ = 0.33 μM). RHPS4 is a DNA damage inducer.

体外研究

RHPS4 could sensitize tumor cells to anticancer agents that act via disparate mechanisms.
RHPS4 (0.5-1 μM, 15 days) induces a senescent-like growth arrest in MCF-7 cells.
RHPS4 (1 μM, 4 days) induces phosphorylation of H2AX in transformed and tumor cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	MCF-7, MCF-7 vector control, and MCF-7 c81 cells.
Concentration:	0, 0.2, 0.5, or 1 μM.
Incubation Time:	7 days.
Result:	Inhibited cell proliferation.

体内研究
(In Vivo)

RHPS4 (15 mg/kg, iv, 15 days) treatment produces a marked inhibition of tumor weight (tumor weight inhibition [TWI] about 80%; P < 0.001) in a very short time, and this effect persists for at least 30 days. A complete tumor response is observed in 80% of mice, and 40% are cured.
In all the other tumor xenografts, RHPS4 treatment produces about 50% (P < 0.001) TWI at the nadir of the effect and, more important, results in a delay of tumor growth of about 15 (M14 and PC3) and 10 (HT29 and H460) days.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD-1 male nude (nu/nu) mice, 6–8 weeks old and weighing 22-24 g (H460, CG5 and HT29, PC3 and M14 cancer models).
Dosage:	15 mg/kg.
Administration:	IV, daily for 15 consecutive days.
Result:	Active as a single agent on all the tumors analyzed. CG5 breast xenografts resulted in the most sensitive tumor.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD-1 male nude (nu/nu) mice, 6–8 weeks old and weighing 22-24 g (H460, CG5 and HT29, PC3 and M14 cancer models).
Dosage:	15 mg/kg.
Administration:	IV, daily for 15 consecutive days.
Result:	Active as a single agent on all the tumors analyzed. CG5 breast xenografts resulted in the most sensitive tumor.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD-1 male nude (nu/nu) mice, 6–8 weeks old and weighing 22-24 g (H460, CG5 and HT29, PC3 and M14 cancer models).
Dosage:	15 mg/kg.
Administration:	IV, daily for 15 consecutive days.
Result:	Active as a single agent on all the tumors analyzed. CG5 breast xenografts resulted in the most sensitive tumor.

性状

Solid

溶解性数据

In Vitro:

DMSO : 1 mg/mL (2.18 mM; ultrasonic and warming and heat to 60°C)

H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1811 mL	10.9056 mL	21.8112 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献